CAS 958002-33-0

Bms 791325

Description:

BMS-791325, with the CAS number 958002-33-0, is a small molecule that functions primarily as an inhibitor of the hepatitis C virus (HCV) NS5A protein. This compound is part of a class of antiviral agents that target the replication of HCV, making it significant in the development of treatments for hepatitis C. BMS-791325 exhibits a unique mechanism of action by disrupting the viral life cycle, which is crucial for effective antiviral therapy. The substance is characterized by its ability to demonstrate potent antiviral activity against various HCV genotypes, contributing to its potential use in combination therapies. Additionally, BMS-791325 has undergone various phases of clinical trials to assess its efficacy and safety profile. Its chemical structure includes specific functional groups that enhance its binding affinity to the NS5A protein, which is essential for its therapeutic action. Overall, BMS-791325 represents a promising candidate in the ongoing efforts to combat hepatitis C infections.

Formula: C₃₆H₄₅N₅O₅S

InChI: InChI=1S/C36H45N5O5S/c1-38(2)47(44,45)37-34(42)23-10-14-28-31(16-23)40-21-36(35(43)41-24-11-12-25(41)20-39(3)19-24)18-30(36)29-17-26(46-4)13-15-27(29)33(40)32(28)22-8-6-5-7-9-22/h10,13-17,22,24-25,30H,5-9,11-12,18-21H2,1-4H3,(H,37,42)/t24?,25?,30-,36-/m0/s1

InChI key: InChIKey=ZTTKEBYSXUCBSE-VSBZUFFNSA-N

SMILES: C(=O)([C@@]12[C@@H](C1)C=3C(C=4N(C2)C=5C(C4C6CCCCC6)=CC=C(C(NS(N(C)C)(=O)=O)=O)C5)=CC=C(OC)C3)N7C8CCC7CN(C)C8

Synonyms:

• Cycloprop[d]indolo[2,1-a][2]benzazepine-9-carboxamide, 12-cyclohexyl-N-[(dimethylamino)sulfonyl]-4b,5,5a,6-tetrahydro-3-methoxy-5a-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]-, (4bS,5aR)-
• Cycloprop[d]indolo[2,1-a][2]benzazepine-9-carboxamide, 12-cyclohexyl-N-[(dimethylamino)sulfonyl]-4b,5,5a,6-tetrahydro-3-methoxy-5a-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]-, (4bS,5aR)-
• Beclabuvir
• Beclabuvir(BMS-791325)
• (1aR,12bS)-8-cyclohexyl-N-[(dimethylamino)sulfonyl]-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide
• (1aR,12bS)-8-cyclohexyl-N-[(dimethylamino)sulfonyl]-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Beclabuvir

CAS: 958002-33-0

Beclabuvir

Purity: ≥98%

Molecular weight: 659.84g/mol

Ref: 54-BUP21835

Beclabuvir

CAS: 958002-33-0

Beclabuvir is an investigational antiviral agent, which is synthetically derived with the purpose of targeting the hepatitis C virus (HCV). It functions as a non-nucleoside inhibitor, specifically inhibiting the HCV NS5B RNA-dependent RNA polymerase, a crucial enzyme necessary for viral replication. By obstructing the polymerase activity, Beclabuvir effectively impedes the replication cycle of the virus, thereby reducing viral load in infected individuals.

Formula: C₃₆H₄₅N₅O₅S

Purity: Min. 95%

Molecular weight: 659.84 g/mol

Ref: 3D-INB00233

Beclabuvir

CAS: 958002-33-0

Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.

Formula: C₃₆H₄₅N₅O₅S

Purity: 99.87% - 99.93%

Color and Shape: Solid

Molecular weight: 659.84

Ref: TM-T10493