CAS 958233-07-3

N,N-Diethyl-2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide

Description:

N,N-Diethyl-2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide is a synthetic organic compound characterized by its complex structure, which includes a pyrazolo-pyrimidine core. This compound features multiple functional groups, including an acetamide and a fluoroethoxy substituent, contributing to its potential biological activity. It is typically a solid at room temperature and may exhibit moderate solubility in organic solvents. The presence of the diethyl group suggests it may have lipophilic properties, which can influence its pharmacokinetics and bioavailability. The fluorine atom in the ethoxy group can enhance metabolic stability and alter the compound's interaction with biological targets. This compound is of interest in medicinal chemistry, particularly for its potential therapeutic applications, possibly in the treatment of various diseases. As with many synthetic compounds, its safety profile, including toxicity and environmental impact, would need to be evaluated through appropriate studies.

Formula: C₂₂H₂₇FN₄O₂

InChI: InChI=1S/C22H27FN4O2/c1-5-26(6-2)20(28)14-19-21(17-7-9-18(10-8-17)29-12-11-23)25-27-16(4)13-15(3)24-22(19)27/h7-10,13H,5-6,11-12,14H2,1-4H3

InChI key: InChIKey=FLZZFWBNYJNHMY-UHFFFAOYSA-N

SMILES: C(C(N(CC)CC)=O)C1=C2N(N=C1C3=CC=C(OCCF)C=C3)C(C)=CC(C)=N2

Synonyms:

• Pyrazolo[1,5-a]pyrimidine-3-acetamide, N,N-diethyl-2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethyl-
• 2-[2-[4-(2-Fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide
• N,N-Diethyl-2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide
• DPA 714
• N,N-diethyl-2-[2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]acetamide

DPA-714

CAS: 958233-07-3

DPA-714: a TSPO ligand (Ki=7 nM) with a fluorine atom for PET imaging of inflammation and brain tumors.

Formula: C₂₂H₂₇FN₄O₂

Purity: 99.52%

Color and Shape: Solid

Molecular weight: 398.47

Ref: TM-T15162

DPA-714

CAS: 958233-07-3

DPA-714

Purity: ≥98%

Molecular weight: 398.47g/mol

Ref: 54-BUP04087

DPA-714

CAS: 958233-07-3

DPA-714 is a nucleophilic agent which is metabolized by cytochrome P450 (CYP) 3A4 to its active form, fluoroacetic acid. This drug has immunomodulatory effects, and it has been shown to reduce the uptake of fluoroacetic acid by microglia cells. DPA-714 also inhibits the production of inflammatory cytokines such as IL-6 in human macrophages. DPA-714 has been shown to be effective against bowel disease in rats, and it may have therapeutic potential for treatment of inflammatory bowel disease in humans. DPA-714 binds to the activated receptor on microglia cells, leading to activation and proliferation of these cells. It also binds to the occipital cortex with high affinity, suggesting that this drug may have potential for treating brain disorders such as Alzheimer’s Disease.

Formula: C₂₂H₂₇FN₄O₂

Purity: Min. 95%

Molecular weight: 398.5 g/mol

Ref: 3D-INB23307