Corosolic Acid β, with the CAS number 958237-73-5, is a naturally occurring triterpenoid compound primarily found in various plant species, particularly in the leaves of the Lagerstroemia speciosa (commonly known as the banaba tree). This compound is characterized by its pentacyclic structure, which contributes to its biological activity. Corosolic Acid β is known for its potential health benefits, including anti-diabetic properties, as it may help regulate blood glucose levels by enhancing insulin sensitivity. Additionally, it exhibits antioxidant and anti-inflammatory effects, making it of interest in the field of nutraceuticals and herbal medicine. The compound is typically extracted from plant sources and may be utilized in dietary supplements. Its safety profile and efficacy are subjects of ongoing research, and while it shows promise, further studies are needed to fully understand its mechanisms and therapeutic potential. As with any bioactive compound, it is essential to consider dosage and potential interactions with other substances when used for health purposes.

Corosolic acid β is a synthetic pentacyclic triterpenoid and derivative of corosolic acid (Item No. 27887) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and siRNA in vitro and in vivo.1 It also inhibits glycogen phosphorylase (IC50 = 82.5 µM for the rabbit muscle enzyme).2 LNPs containing corosolic acid β and encapsulating an mRNA reporter show greater transfection efficiency than those containing cholesterol (Item Nos. 9003100 | 39088) in 4T1, B16/F10, and HeLa cells.1 Corosolic acid β-containing LNPs selectively accumulate in tumors and do not accumulate in the liver compared with cholesterol-containing LNPs, which accumulate in both, following intratumoral injection. LNPs containing corosolic acid β and encapsulating siRNA targeting mRNA encoding Bcl-2 decrease tumor volume and lung metastasis and increase survival in a 4T1 murine mammary carcinoma model.WARNING This product is not for human or veterinary use.

Corosolic Acid β

958237-73-5: Corosolic Acid β, with the CAS number 958237-73-5, is a naturally occurring triterpenoid compound primarily found in various plant species, particularly in the leaves of the Lagerstroemia speciosa (commonly known as the banaba tree). This compound is characterized by its pentacyclic structure, which contributes to its biological activity. Corosolic Acid β is known for its potential health benefits, including anti-diabetic properties, as it may help regulate blood glucose levels by enhancing insulin sensitivity. Additionally, it exhibits antioxidant and anti-inflammatory effects, making it of interest in the field of nutraceuticals and herbal medicine. The compound is typically extracted from plant sources and may be utilized in dietary supplements. Its safety profile and efficacy are subjects of ongoing research, and while it shows promise, further studies are needed to fully understand its mechanisms and therapeutic potential. As with any bioactive compound, it is essential to consider dosage and potential interactions with other substances when used for health purposes.

<p>RMGPa-IN-1 (Compound 10C) is an inhibitor of rabbit muscle glycogen phosphorylase a (RMGPa), exhibiting an IC50 value of 82.5 μM. This compound holds potential for research in diabetes.</p>

CAS 958237-73-5

Corosolic Acid β

RMGPa-IN-1

Ref: TM-T206441