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CAS 959-24-0

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Sotalol hydrochloride

Description:
Sotalol hydrochloride is a pharmaceutical compound primarily used as an antiarrhythmic agent in the treatment of certain types of cardiac arrhythmias, particularly atrial fibrillation and ventricular tachycardia. It is a racemic mixture of two enantiomers, Sotalol and its D-enantiomer, which exhibit different pharmacological properties. The substance is characterized by its ability to block beta-adrenergic receptors, leading to a decrease in heart rate and myocardial contractility. Additionally, Sotalol has a significant effect on prolonging the cardiac action potential, which helps to stabilize heart rhythm. It is typically administered orally and is well-absorbed in the gastrointestinal tract. The hydrochloride salt form enhances its solubility and stability. Common side effects may include fatigue, dizziness, and gastrointestinal disturbances. Due to its effects on heart rhythm, careful monitoring is required during treatment, especially in patients with renal impairment or those taking other medications that affect cardiac function. Overall, Sotalol hydrochloride is a critical medication in managing specific cardiac conditions, with a well-established profile in clinical use.
Formula:C12H20N2O3S·ClH
InChI:InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
InChI key:InChIKey=VIDRYROWYFWGSY-UHFFFAOYSA-N
SMILES:C(CNC(C)C)(O)C1=CC=C(NS(C)(=O)=O)C=C1.Cl
Synonyms:
  • 4-(1-Hydroxy-2-Isopropylaminoethyl)Methanesulphonanilide Hydrochloride
  • 4′-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide hydrochloride
  • 4′-[2-(Isopropylamino)-1-hydroxyethyl]methanesulfonanilide hydrochloride
  • 4′-[2-(Isopropylamino)-1-hydroxyethyl]methanesulfonanilide monohydrochloride
  • <span class="text-smallcaps">D</smallcap><smallcap>L</span>-MJ 1999
  • Betapace
  • Darob
  • Methanesulfonamide, N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-, hydrochloride (1:1)
  • Methanesulfonamide, N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-, monohydrochloride
  • Methanesulfonanilide, 4′-[1-hydroxy-2-(isopropylamino)ethyl]-, monohydrochloride
  • See more synonyms
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