CAS 95975-55-6

Guggulsterone

Description:

Guggulsterone is a phytosterol derived from the resin of the Commiphora mukul tree, commonly found in India and other parts of Asia. It is known for its potential therapeutic properties, particularly in traditional medicine, where it has been used for weight management and cholesterol regulation. Guggulsterone exists in two isomeric forms, E and Z, with the E-isomer being more biologically active. The compound exhibits a range of biological activities, including anti-inflammatory, antioxidant, and lipid-lowering effects, which have garnered interest in the fields of pharmacology and nutrition. Guggulsterone is also recognized for its role in modulating thyroid function, potentially influencing metabolism. Its mechanism of action involves interaction with nuclear receptors, particularly the farnesoid X receptor (FXR) and the liver X receptor (LXR), which play crucial roles in lipid metabolism. While guggulsterone is generally considered safe, its efficacy and safety profile should be evaluated in the context of clinical use, as individual responses may vary.

Formula: C₂₁H₂₈O₂

InChI: InChI=1/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1

InChI key: InChIKey=WDXRGPWQVHZTQJ-NRJJLHBYSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC(=O)C2=CC)[H]

Synonyms:

• (17E)-Pregna-4,17(20)-diene-3,16-dione
• (17Z)-pregna-4,17-diene-3,16-dione
• (8alpha,9beta,17E)-20-methoxypregna-4,17-diene-3,16-dione
• Guggulsterone
• Guggulsterone E&Z
• Guggulsterones E&Z
• Guglip
• Gugulipid
• Pregna-4,17(20)-diene-3,16-dione
• Pregna-4,17-diene-3,16-dione
• Z/E-Guggulsterone
• (Z)-Guggulsterone
• GUGGULISTERONES 95%
• GUGGULESTERONE Z
• GUGULSTERONE
• (8S,9R,10R,13S,14S,17E)-17-(1-methoxyethylidene)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
• CIS-4,17(20)-PREGNADIENE-3,16-DIONE
• GUGGULSTERONE (Z FORM)
• (Z)-GUGGULSTERONE
• CIS GUGGULSTERONE
• 4,17(20)-(CIS)-PREGNADIEN-3,16-DIONE
• (17Z)-Pregna-4,17(20)-diene-3,16-dione

Guggulsterone

CAS: 95975-55-6

Guggulsterone

Purity: ≥98%

Molecular weight: 312.45g/mol

Ref: 54-BUP04841

Guggulsterone E&Z

CAS: 95975-55-6

Formula: C₂₁H₂₈O₂

Molecular weight: 312.45

Ref: 7W-GY5474

Guggulsterone [mixture of (E)- and (Z)- isomers]

CAS: 95975-55-6

Formula: C₂₁H₂₈O₂

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 312.45

Ref: 3B-G0629

Guggulsterone E&Z

CAS: 95975-55-6

Formula: C₂₁H₂₈O₂

Purity: 95%~99%

Molecular weight: 312.453

Ref: BP-BP0692

Guggulsterone

CAS: 95975-55-6

Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.

Formula: C₂₁H₂₈O₂

Purity: 99.4% - 99.8%

Color and Shape: Light Yellow Powder

Molecular weight: 312.45

Ref: TM-T5574

Z/E-Guggulsterone

Controlled Product

CAS: 95975-55-6

Applications Guggulsterone is a broad spectrum steroid receptor ligand. Gum resin of Commiphora mukul marketed as an antihyperlipidemic drug.
References Yang, D. et al.: J. Lipid Res., 53, 529 (2012); El-Mekkawy, S. et al.: Nat. Prod. Res., 27, 146 (2013); Chhonker, Y. et al.: Drug. Test. Anal., 8, 966 (2016);

Formula: C₂₁H₂₈O₂

Color and Shape: Neat

Molecular weight: 312.45

Ref: TR-G852003

(Z&E)-Guggulsterone

Controlled Product

CAS: 95975-55-6

(Z&E)-Guggulsterone is a steroidal compound, derived from the resin of the Commiphora mukul plant, commonly known as Guggul. This plant source has been traditionally utilized in Ayurvedic medicine, and modern extraction techniques allow for the isolation of guggulsterones, including the (Z&E) isomers, which are recognized for their bioactive properties. The mode of action for (Z&E)-Guggulsterone involves the modulation of nuclear receptors, specifically the farnesoid X receptor (FXR) and the estrogen receptor, which play crucial roles in lipid metabolism and inflammatory pathways. This modulation can lead to lowered cholesterol levels and an anti-inflammatory effect.

Formula: C₂₁H₂₈O₂

Purity: Min. 95%

Color and Shape: Off-White Yellow Powder

Molecular weight: 312.45 g/mol

Ref: 3D-FG41868