CAS 961-45-5

8-Phenyltheophylline

Description:

8-Phenyltheophylline is a chemical compound that belongs to the class of xanthines, which are known for their stimulant properties. It is a derivative of theobromine and theophylline, characterized by the presence of a phenyl group at the 8-position of the xanthine structure. This modification enhances its pharmacological profile, making it a useful compound in research, particularly in studies related to adenosine receptors and their role in various physiological processes. The compound is typically a white to off-white crystalline powder and is soluble in organic solvents but has limited solubility in water. Its molecular formula reflects a complex structure that contributes to its biological activity, including potential effects on smooth muscle relaxation and modulation of neurotransmitter release. 8-Phenyltheophylline is often utilized in pharmacological studies to investigate its effects on the central nervous system and cardiovascular system, as well as its potential therapeutic applications. As with many xanthine derivatives, it may exhibit side effects related to its stimulant properties, necessitating careful consideration in experimental contexts.

Formula: C₁₃H₁₂N₄O₂

InChI: InChI=1S/C13H12N4O2/c1-16-11-9(12(18)17(2)13(16)19)14-10(15-11)8-6-4-3-5-7-8/h3-7H,1-2H3,(H,14,15)

InChI key: InChIKey=PJFMAVHETLRJHJ-UHFFFAOYSA-N

SMILES: O=C1C2=C(N=C(N2)C3=CC=CC=C3)N(C)C(=O)N1C

Synonyms:

• 1,2,3,6-Tetrahydro-1,3-Dimethyl-2,6-Dioxo-8-Phenylpurine
• 1,3-Dimethyl-8-phenyl-1H-purine-2,6(3H,7H)-dione
• 1,3-dimethyl-8-phenyl-3,7-dihydro-1H-purine-2,6-dione
• 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-8-phenyl-
• 1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-8-phenyl-
• 3,7-Dihydro-1,3-dimethyl-8-phenyl-1H-purine-2,6-dione
• 3,9-Dihydro-1,3-dimethyl-8-phenyl-1H-purine-2,6-dione
• 8-Phenyl-1,3-dimethylxanthine
• 8-Phenyltheophylline
• NSC 14127
• Theophylline, 8-phenyl-

1,3-Dimethyl-8-phenylxanthine

CAS: 961-45-5

Formula: C₁₃H₁₂N₄O₂

Purity: ≥ 95%

Color and Shape: White to off-white or pale yellow crystalline powder

Molecular weight: 256.26

Ref: 7W-GL3928

1,3-Dimethyl-8-phenylxanthine

Controlled Product

CAS: 961-45-5

Applications 1,3-Dimethyl-8-phenylxanthine is a non-selective adenosine receptor antagonist prevents the anticonvulsant effect of curcumin.
References Akula, K. K., et al.: Phytoth. Res., 28, 714-721 (2014)

Formula: C₁₃H₁₂N₄O₂

Color and Shape: Neat

Molecular weight: 256.26

Ref: TR-D480168

8-Phenyltheophylline

Controlled Product

CAS: 961-45-5

8-Phenyltheophylline (8PT) is an adenosine receptor agonist that is used as a bronchodilator for the treatment of asthma. It has been shown to increase the intracellular calcium concentration in hl-60 cells and in rat papillary muscles. 8PT also has locomotor activating effects, which are thought to be due to its ability to block potassium channels in the hippocampal formation. These effects may be related to ATP-sensitive potassium channels, which have been shown to be sensitive to ATP in untreated mice. 8PT also has anti-arrhythmic properties, which may be due to its ability to inhibit sodium channels and its effect on heart rate and contractility.

Formula: C₁₃H₁₂N₄O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 256.26 g/mol

Ref: 3D-FP165348