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CAS 96125-53-0

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Clentiazem

Description:
Clentiazem is a chemical compound classified as a benzothiazepine derivative, primarily known for its pharmacological properties. It functions as a calcium channel blocker, which means it inhibits the influx of calcium ions into cardiac and smooth muscle cells, leading to vasodilation and reduced heart rate. This mechanism makes Clentiazem useful in the treatment of cardiovascular conditions such as hypertension and angina. The compound exhibits a moderate lipophilicity, allowing it to penetrate biological membranes effectively. Clentiazem's structure includes a benzothiazepine core, which contributes to its biological activity and interaction with calcium channels. Additionally, it may have varying solubility in different solvents, influencing its bioavailability and pharmacokinetics. As with many pharmaceuticals, the safety profile, potential side effects, and interactions with other medications are important considerations in its therapeutic use. Overall, Clentiazem represents a significant compound in the realm of cardiovascular pharmacotherapy, with its unique properties contributing to its clinical applications.
Formula:C22H25ClN2O4S
InChI:InChI=1S/C22H25ClN2O4S/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3/h5-10,13,20-21H,11-12H2,1-4H3/t20-,21+/m1/s1
InChI key:InChIKey=GYKFWCDBQAFCLJ-RTWAWAEBSA-N
SMILES:O(C(C)=O)[C@@H]1[C@@H](SC=2C(N(CCN(C)C)C1=O)=CC=C(Cl)C2)C3=CC=C(OC)C=C3
Synonyms:
  • (+)-cis-2-(4-Methoxyphenyl)-3-acetoxy-5-(2-(N,N-dimethylamino)ethyl)-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
  • (2S,3S)-3-(Acetyloxy)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-8-chloro-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (25-cis)-
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-8-chloro-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-
  • Clentiazem [INN]
  • Clentiazemum
  • Clentiazemum [INN-Latin]
  • Unii-40Dk034Drc
  • Clentiazem
  • Clentiazem
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Found 3 products.
  • Clentiazem
    TRC
    + Info

    Clentiazem

    Controlled Product
    CAS:

    Applications Clentiaze is a benzothiazepine-like calcium antagonists; Enhances endothelium-dependent coronary artery relaxation.
    References Tanguay, M., et al.: Can. J. Physiol. Pharmacol., 73, 1108-1117 (1995); Dagenais, F., et al.: Can. J. Cardiol., 11, 816-822 (1995)

    Formula:C22H25ClN2O4S
    Color and Shape:Neat
    Molecular weight:448.96

    Ref: TR-C573035

    1mg
    320.00€
    10mg
    2,056.00€
  • Clentiazem-d6
    TRC
    + Info

    Clentiazem-d6

    Controlled Product
    CAS:
    Formula:C22D6H19ClN2O4S
    Color and Shape:Neat
    Molecular weight:455.0

    Ref: TR-C573037

    75mg
    17,136.00€
  • Clentiazem (free base)
    Targetmol
    + Info

    Clentiazem (free base)

    CAS:
    Clentiazem (free base) is a calcium channel blocker. It is a chlorine derivative of diltiazem.
    Formula:C22H25ClN2O4S
    Color and Shape:Solid
    Molecular weight:448.96

    Ref: TM-T68221

    25mg
    1,773.00€
    50mg
    2,322.00€
    100mg
    3,060.00€