CAS 96128-92-6

Clentiazem maleate

Description:

Clentiazem maleate is a pharmaceutical compound primarily classified as a calcium channel blocker, which is used in the treatment of cardiovascular conditions, particularly hypertension and angina. It functions by inhibiting the influx of calcium ions into cardiac and smooth muscle cells, leading to vasodilation and reduced myocardial oxygen demand. The maleate salt form enhances its solubility and stability, making it suitable for formulation in various dosage forms. Clentiazem exhibits a relatively high affinity for L-type calcium channels, contributing to its efficacy in managing blood pressure and heart rate. The compound is typically administered orally and is characterized by its moderate lipophilicity, which influences its absorption and distribution in the body. As with many medications, potential side effects may include dizziness, headache, and gastrointestinal disturbances. It is essential for patients to consult healthcare professionals for appropriate dosing and to discuss any contraindications or interactions with other medications. Overall, Clentiazem maleate represents a significant therapeutic option in the management of cardiovascular diseases.

Formula: C₂₂H₂₅ClN₂O₄S·C₄H₄O₄

SMILES: O(C(C)=O)[C@@H]1[C@@H](SC=2C(N(CCN(C)C)C1=O)=CC=C(Cl)C2)C3=CC=C(OC)C=C3.C(=C\C(O)=O)\C(O)=O

Synonyms:

• 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-, (2Z)-2-butenedioate (1:1)
• TA 3090
• 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-, (Z)-2-butenedioate (1:1)
• (S,S)-Clentiazem maleate
• Clentiazem maleate

Clentiazem maleate

CAS: 96128-92-6

Clentiazem maleate is a calcium channel antagonist .

Formula: C₂₆H₂₉ClN₂O₈S

Color and Shape: Solid

Molecular weight: 565.034

Ref: TM-T68220