CAS 96187-53-0

Brequinar

Description:

Brequinar, with the CAS number 96187-53-0, is a synthetic compound that belongs to the class of quinoline derivatives. It is primarily known for its role as an immunosuppressive agent and has been investigated for its potential in cancer therapy due to its ability to inhibit dihydroorotate dehydrogenase, an enzyme involved in the de novo synthesis of pyrimidines. Brequinar exhibits a moderate solubility in organic solvents and is typically administered in a pharmaceutical context. Its mechanism of action involves the disruption of nucleotide synthesis, which can lead to the inhibition of cell proliferation, particularly in lymphocytes. The compound has been studied in various preclinical and clinical settings, although its clinical use has been limited. Safety and efficacy profiles are essential considerations in its application, and ongoing research continues to explore its therapeutic potential and optimize its use in combination with other treatments. As with any pharmacological agent, understanding its pharmacokinetics, metabolism, and potential side effects is crucial for its application in medicine.

Formula: C₂₃H₁₅F₂NO₂

InChI: InChI=1S/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H,1H3,(H,27,28)

InChI key: InChIKey=PHEZJEYUWHETKO-UHFFFAOYSA-N

SMILES: CC=1C(=NC2=C(C1C(O)=O)C=C(F)C=C2)C3=CC=C(C=C3)C4=C(F)C=CC=C4

Synonyms:

• 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro(1,1'-biphenyl)-4-yl)-3-methyl-
• 6-Fluoro-2-(2'-Fluorobiphenyl-4-Yl)-3-Methylquinoline-4-Carboxylic Acid
• 6-Fluoro-2-(2′-fluoro[1,1′-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid
• Biphenquinate
• Brequinar [INN]
• Brequinarum
• Brequinarum [INN-Latin]
• Dup 785
• Unii-5Xl19F49H6
• brequinarum [Latin]
• Brequinar

6-FLUORO-2-(2'-FLUORO-[1,1'-BIPHENYL]-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID

CAS: 96187-53-0

Formula: C₂₃H₁₅F₂NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 375.3675

Ref: IN-DA006SF2

Brequinar

CAS: 96187-53-0

Brequinar

Purity: 98%

Molecular weight: 375.37g/mol

Ref: 54-PC108447

Brequinar

CAS: 96187-53-0

Brequinar

Purity: ≥98%

Molecular weight: 375.37g/mol

Ref: 54-BUP13078

Brequinar

CAS: 96187-53-0

Formula: C₂₃H₁₅F₂NO₂

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 375.37

Ref: 3B-B5707

Brequinar

CAS: 96187-53-0

Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.

Formula: C₂₃H₁₅F₂NO₂

Purity: 99.1% - 99.57%

Color and Shape: Solid

Molecular weight: 375.37

Ref: TM-T5013

6-Fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid

CAS: 96187-53-0

Brequinar sodium is a drug that belongs to the class of quinoline carboxylic acid derivatives. It has been shown to be effective in the treatment of infectious diseases and bowel disease. Brequinar sodium inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Brequinar also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

Formula: C₂₃H₁₅F₂NO₂

Purity: Min. 97 Area-%

Color and Shape: White/Off-White Solid

Molecular weight: 375.37 g/mol

Ref: 3D-FF44184

6-Fluoro-2-(2′-fluoro-[1,1′-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid

CAS: 96187-53-0

Formula: C₂₃H₁₅F₂NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 375.375

Ref: 10-F080292