CAS 96515-73-0

Palonidipine

Description:

Palonidipine is a calcium channel blocker primarily used in the treatment of hypertension and certain cardiovascular conditions. It belongs to the dihydropyridine class of calcium antagonists, which function by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissues. This action leads to vasodilation, reduced peripheral resistance, and ultimately lowers blood pressure. Palonidipine is characterized by its high selectivity for vascular tissues, which minimizes potential side effects commonly associated with other calcium channel blockers. Additionally, it has a long half-life, allowing for once-daily dosing, which enhances patient compliance. The compound exhibits good oral bioavailability and is metabolized primarily in the liver. Its pharmacological profile includes not only antihypertensive effects but also potential benefits in improving endothelial function. As with any medication, it is essential to consider contraindications and potential interactions with other drugs when prescribing Palonidipine.

Formula: C₂₉H₃₄FN₃O₆

InChI: InChI=1/C29H34FN3O6/c1-18-24(27(34)38-6)26(22-14-21(33(36)37)12-13-23(22)30)25(19(2)31-18)28(35)39-17-29(3,4)16-32(5)15-20-10-8-7-9-11-20/h7-14,26,31H,15-17H2,1-6H3

SMILES: CC1=C(C(c2cc(ccc2F)N(=O)=O)C(=C(C)N1)C(=O)OCC(C)(C)CN(C)Cc1ccccc1)C(=O)OC

Synonyms:

• Palonidipine [INN]
• (+-)-3-(Benzylmethylamino)-2,2-dimethylpropyl methyl 4-(2-fluoro-5-nitrophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
• Unii-Fms4X67Q96
• (- )-3-(Benzylmethyl-amino)-2,2-dimethylpropyl methyl 4-(2-fluoro-5-nitrophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate.
• 3-[Benzyl(Methyl)Amino]-2,2-Dimethylpropyl Methyl 4-(2-Fluoro-5-Nitrophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate
• Palonidipine
• 5-O-[3-[benzyl(methyl)amino]-2,2-dimethylpropyl] 3-O-methyl 4-(2-fluoro-5-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• 1,4-Dihydro-4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine-3,5-dicarboxylic acid 3-[3-(N-benzylmethylamino)-2,2-dimethylpropyl]5-methyl ester
• O3-[2,2-dimethyl-3-[methyl(phenylmethyl)amino]propyl] O5-methyl 4-(2-fluoro-5-nitro-phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• 1,4-Dihydro-4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine-3,5-dicarboxylic acid 3-methyl 5-[3-[benzyl(methyl)amino]-2,2-dimethylpropyl] ester
• 3-O-[2,2-dimethyl-3-[methyl(phenylmethyl)amino]propyl] 5-O-methyl 4-(2-fluoro-5-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Palonidipine

CAS: 96515-73-0

Palonidipine is an experimental pharmaceutical compound classified as a calcium channel blocker, which is derived from synthetic chemical processes. This product functions by inhibiting the influx of calcium ions through L-type calcium channels located on the vascular smooth muscle cells and cardiac myocytes. By blocking these channels, Palonidipine causes vasodilation, reducing systemic vascular resistance, and thereby lowering blood pressure.

Formula: C₂₉H₃₄FN₃O₆

Purity: Min. 95%

Molecular weight: 539.6 g/mol

Ref: 3D-WDA51573

Palonidipine

CAS: 96515-73-0

Palonidipine is an antagonist of calcium, is potential for the therapy of angina-pectoris and hypertension.

Formula: C₂₉H₃₄FN₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 539.6

Ref: TM-T12358