CAS 96736-12-8

L-Leucinamide,D-arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-

Description:

L-Leucinamide, D-arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl- is a complex peptide composed of various amino acids, including both L- and D-enantiomers. This structure suggests that it may exhibit unique biological properties due to the presence of both forms of amino acids, which can influence its interactions with biological systems. The presence of multiple proline residues may contribute to its structural stability and potential for forming specific conformations. The peptide's sequence indicates a potential role in biological processes, possibly related to signaling or structural functions in proteins. Its CAS number, 96736-12-8, allows for precise identification in chemical databases. However, detailed information regarding its solubility, stability, and specific biological activities would require empirical studies, as these characteristics can vary significantly based on the peptide's conformation and environment. Overall, this compound represents a fascinating area of study in peptide chemistry and biochemistry.

Formula: C₇₉H₁₀₉N₁₉O₁₂

Synonyms:

• SubstanceP,1-D-arginine-5-D-phenylalanine-7-D-tryptophan-9-D-tryptophan-11-L-leucinamide-
• L 756867
• [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P
• D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2

(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P

CAS: 96736-12-8

(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P initially described as a low potency ghrelin receptor antagonist has surprisingly been found to be a full inverse agonist (EC₅₀ = 5.2 nM). In COS-7 cells transiently transfected with the ghrelin receptor the substance P analog rPKPfQwFwLL decreased the constitutive signaling down to levels observed in untransfected cells. Assuming that constitutive signaling of the ghrelin receptor is of physiological relevance in the regulation of appetite control, inverse agonists of the ghrelin receptor could be interesting for the treatment of obesity. So, Asakawa et al. found that peripherally administered H-6395 decreased food intake in lean mice, in mice with diet induced obesity, and in ob/ob obese mice.

Formula: C₇₉H₁₀₉N₁₉O₁₂

Purity: 98.2%

Color and Shape: White Lyophilisate

Molecular weight: 1516.86

Ref: 01-4013823

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

CAS: 96736-12-8

Broad-spectrum inverse agonist; potent at ghrelin receptor (EC50=5.2 nM); blocks other neuropeptide receptors; induces apoptosis; inhibits tumor growth.

Formula: C₇₉H₁₀₉N₁₉O₁₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 1516.85

Ref: TM-TP1931

[D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P

CAS: 96736-12-8

Formula: C₇₉H₁₀₉N₁₉O₁₂

Purity: ≥ 95.0%

Color and Shape: White powder

Molecular weight: 1516.83

Ref: 7W-GL9471

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

CAS: 96736-12-8

Substance P is a neuropeptide that belongs to the Feeding Regulatory Peptides family. It is synthesized in the hypothalamus and secreted by neurons in the spinal cord, brainstem, and gut. Substance P has been shown to regulate feeding behavior through its interaction with opioid receptors and the release of other neurotransmitters. The synthetic form of this peptide has been shown to reduce body fat in animal models and increased sensitivity to insulin in diabetic patients. This peptide also reduces camp levels in rats, which may be due to its ability to stimulate secretion of camp from pancreatic cells.

Formula: C₇₉H₁₀₉N₁₉O₁₂

Purity: Min. 95%

Molecular weight: 1,516.87 g/mol

Ref: 3D-PGH-3652-PI

(D-Arg1,D-Phe5,D-Trp7·9,Leu11)-Substance P

CAS: 96736-12-8

Substance P is a neuropeptide that binds to the tachykinin receptor NK1. It has potent anti-inflammatory and mitogenic activities, which are mediated through its binding to the NK1 receptor. Substance P can stimulate lung cancer cells to proliferate and inhibit their apoptosis, which may be due to an autocrine mechanism. In addition, it has been shown that substance P can potentiate the growth of some cancers such as colon cancer in vitro and in vivo by increasing DNA synthesis and cell proliferation. This peptide also has a dose-dependent effect on cell growth, with high doses inhibiting cell proliferation at higher levels than low doses.

Formula: C₇₉H₁₀₉N₁₉O₁₂

Purity: Min. 95%

Molecular weight: 1,516.83 g/mol

Ref: 3D-FA109992