CAS 96737-93-8

Pregnan-20-one-17,21,21,21-d4,3-hydroxy-, (3a,5b)- (9CI)

Description:

Pregnan-20-one-17,21,21,21-d4,3-hydroxy-, (3a,5b)-, commonly referred to as a deuterated form of a steroid hormone, is a synthetic derivative of progesterone. This compound features a hydroxyl group at the 3-position and is characterized by the presence of deuterium isotopes at specific carbon positions, which can be useful in various biochemical studies, particularly in tracing metabolic pathways. The deuteration enhances the stability and detection of the compound in analytical techniques such as mass spectrometry. As a steroid, it exhibits typical characteristics of steroid hormones, including lipophilicity, the ability to cross cell membranes, and the potential to bind to specific receptors, influencing various physiological processes. Its structural configuration, particularly the (3a,5b) stereochemistry, plays a crucial role in its biological activity and interaction with hormone receptors. This compound is primarily used in research settings, particularly in studies related to hormonal regulation and metabolism.

Formula: C₂₁H₃₀D₄O₂

Synonyms:

• 5B-Pregnan-3A-Ol-20-One-17,21,21,21-D4

5β-Pregnan-3α-ol-20-one-17,21,21,21-d4

CAS: 96737-93-8

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 322.52

Ref: 3U-D6579

5β-Pregnan-3α-ol-20-one-d4 (contains 10% toluene)

Controlled Product

CAS: 96737-93-8

Applications 5β-Pregnan-3α-ol-20-one-d4 is a labelled analogue of 5β-Pregnan-3α-ol-20-one (P711300), which is a hyponotic-anaesthetic agent. It is also an intermediate in synthesizing Pregnanediol-d5 3α-O-β-D-Glucuronide (P705142), which is a glucuronide conjugate of Pregnanediol (P705130). Levels of Pregnanediol 3α-O-β-D-Glucuronide can be used to monitor the reproductive status of dairy cows. 3α-O-β-D-Glucuronide can be used (as an alternative to creatine) as a reference to adjust other hormonal markers in study of urinary hormonal profiles in the human menstrual cycle.
References Yang, C.J. et al.: Asian-Austral. J. Anim. Sci., 17, 460 (2004); Miro, F. et al.: Clin. Chem. Lab. Med., 42, 1043 (2004); Gyermek, et al.: J. Med. Chem., 11, 117 (1968);

Formula: C₂₁D₄H₃₀O₂

Color and Shape: Neat

Molecular weight: 322.52

Ref: TR-P711302

5Beta-Pregnan-3alpha-ol-20-one-17alpha,21,21,21-d4

CAS: 96737-93-8

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Formula: C₂₁H₃₄O₂

Purity: Min. 95%

Molecular weight: 322.50 g/mol

Ref: 3D-WDA73793