CAS 96829-58-2

Tetrahydrolipstatin

Description:

Tetrahydrolipstatin, also known as orlistat, is a potent lipase inhibitor primarily used in the management of obesity. It functions by inhibiting pancreatic lipase, an enzyme responsible for the breakdown of dietary fats into absorbable free fatty acids. This inhibition leads to a reduction in fat absorption from the gastrointestinal tract, promoting weight loss. Tetrahydrolipstatin is a white to off-white powder that is practically insoluble in water but soluble in organic solvents. Its molecular structure includes a lactone ring and a long fatty acid chain, contributing to its lipophilic nature. The compound is typically administered in capsule form and is often used in conjunction with a reduced-calorie diet and exercise for effective weight management. Side effects may include gastrointestinal discomfort, such as oily stools and flatulence, due to unabsorbed fats. Overall, tetrahydrolipstatin represents a unique approach to weight loss by targeting fat absorption rather than appetite suppression.

Formula: C₂₉H₅₃NO₅

InChI: InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1

InChI key: InChIKey=AHLBNYSZXLDEJQ-FWEHEUNISA-N

SMILES: C([C@@H](OC([C@H](CC(C)C)NC=O)=O)CCCCCCCCCCC)[C@H]1[C@H](CCCCCC)C(=O)O1

Synonyms:

• (-)-Tetrahydrolipstatin
• (1S)-1-{[(2R,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}dodecyl N-formyl-D-leucinate
• (S)-2-Formylamino-4-Methyl-Pentanoic Acid (S)-1-[[(2S,3S)-3-Hexyl-4-Oxo-2-Oxetanyl]Methyl]-Dodecyl Ester
• <span class="text-smallcaps">L</span>-Leucine, N-formyl-, (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
• <span class="text-smallcaps">L</span>-Leucine, N-formyl-, 1-[(3-hexyl-4-oxo-2-oxetanyl)methyl]dodecyl ester, [2S-[2α(R*),3β]]-
• Listata
• N-Formyl-L-Leucine (1S)-1-[[(2S,3S)-3-Hexyl-4-Oxo-2-Oxetanyl]Methyl]Dodecyl Ester
• Orlipastat
• Ro 18-0647/002
• Ro-18-0647
• Xenical
• [(1S)-1-[[(2S)-3-hexyl-4-oxo-oxetan-2-yl]methyl]dodecyl] (2S)-2-formamido-4-methyl-pentanoate
• L-Leucine, N-formyl-, 1-[(3-hexyl-4-oxo-2-oxetanyl)methyl]dodecyl ester, [2S-[2α(R*),3β]]-

Orlistat

CAS: 96829-58-2

Formula: C₂₉H₅₃NO₅

Purity: >97.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 495.75

Ref: 3B-O0381

Orlistat, 98%

CAS: 96829-58-2

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL

Formula: C₂₉H₅₃NO₅

Purity: 98%

Molecular weight: 495.73

Ref: 02-J62999

Orlistat

CAS: 96829-58-2

Lactones, nesoi

Formula: C₂₉H₅₃NO₅

Color and Shape: White Powder

Molecular weight: 495.39237

Ref: 45-1478800

Orlistat

CAS: 96829-58-2

Orlistat (Tetrahydrolipstatin) is a lipase inhibitor and a FASN inhibitor. Orlistat has been shown to promote weight loss. Cost effective and quality assured.

Formula: C₂₉H₅₃NO₅

Purity: 99.58% - >99.99%

Color and Shape: White Crystalline Powder

Molecular weight: 495.73

Ref: TM-T0686

(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate

CAS: 96829-58-2

Formula: C₂₉H₅₃NO₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 495.7348

Ref: IN-DA0035FN

Orlistat Powder

CAS: 96829-58-2

Orlistat Powder

Purity: 98%

Molecular weight: 495.73g/mol

Ref: 54-OR1029653

Orlistat

CAS: 96829-58-2

Orlistat

Purity: ≥98%

Molecular weight: 495.73g/mol

Ref: 54-BUP17083

Orlistat

CAS: 96829-58-2

Formula: C₂₉H₅₃NO₅

Purity: ≥ 97.0%

Color and Shape: White to almost white powder or solid

Molecular weight: 495.73

Ref: 7W-GP9255

Orlistat

CAS: 96829-58-2

Formula: C₂₉H₅₃NO₅

Color and Shape: White To Off-White Solid

Molecular weight: 495.75

Ref: 4Z-O-183

Orlistat

CAS: 96829-58-2

Formula: C₂₉H₅₃NO₅

Color and Shape: Neat

Molecular weight: 495.73

Ref: 04-C15744000

Orlistat

CAS: 96829-58-2

Formula: C₂₉H₅₃NO₅

Color and Shape: Neat

Molecular weight: 495.73

Ref: 86-MM1219.00

Orlistat-d7

CAS: 96829-58-2

Formula: C₂₉H₄₆D₇NO₅

Molecular weight: 502.79

Ref: 4Z-O-01827

Orlistat

Controlled Product

CAS: 96829-58-2

Applications Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.
References Borgstrom, B., et al.: Biochim. Biophys. Acta, 962, 308 (1988), Hauptman, J.B., et al.: Am. J. Clin. Nutr., 55, 309S (1992), McNeely, W., et al.: Drugs, 56, 241 (1998), Hauptman, J. B., et al.: Arch. Fam. Med., 9, 160 (2000),

Formula: C₂₉H₅₃NO₅

Color and Shape: White To Off-White

Molecular weight: 495.73

Ref: TR-O686500

Orlistat - Bio-X ™

CAS: 96829-58-2

Orlistat is a drug that has been approved for the treatment of obesity. It inhibits gastric and pancreatic lipases, which are enzymes that break down dietary fats into smaller molecules to facilitate absorption. Orlistat has been shown to reduce coronary heart disease in patients with type 2 diabetes. Orlistat has also been shown to have a significant upregulation of gene expression associated with disease activity when injected into the skin of patients with primary pulmonary hypertension.
Orlistat is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™  products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₉H₅₃NO₅

Color and Shape: Powder

Molecular weight: 495.73 g/mol

Ref: 3D-BO164179

Orlistat

CAS: 96829-58-2

Lipase inhibitor; semisynthetic derivative of lipstatin

Formula: C₂₉H₅₃NO₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 495.74 g/mol

Ref: 3D-FO26582

Orlistat

CAS: 96829-58-2

Color and Shape: Neat

Ref: 61-FOR1219.00