CAS 96829-59-3

Lipstatin

Description:

Lipstatin, also known as orlistat, is a potent inhibitor of pancreatic lipase, an enzyme crucial for the digestion of dietary fats. It is classified as a lipase inhibitor and is primarily used in the management of obesity. The chemical structure of Lipstatin features a complex lactone ring and a unique fatty acid side chain, which contribute to its biological activity. As a pharmacological agent, it works by preventing the absorption of dietary fats in the intestines, leading to reduced caloric intake. Lipstatin is typically administered orally and is often used in conjunction with a reduced-calorie diet and exercise for effective weight management. Its mechanism of action involves forming a covalent bond with the active site of pancreatic lipase, thereby inhibiting its activity. While effective, Lipstatin can cause gastrointestinal side effects due to unabsorbed fats in the digestive system. Overall, Lipstatin represents a significant advancement in obesity treatment, providing a non-systemic approach to weight management.

Formula: C₂₉H₄₉NO₅

InChI: InChI=1/C29H49NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h12-13,15-16,22-27H,5-11,14,17-21H2,1-4H3,(H,30,31)/b13-12-,16-15-/t24-,25-,26-,27-/m0/s1

InChI key: InChIKey=OQMAKWGYQLJJIA-CUOOPAIESA-N

SMILES: C([C@@H](OC([C@H](CC(C)C)NC=O)=O)C/C=C\C/C=C\CCCCC)[C@H]1[C@H](CCCCCC)C(=O)O1

Synonyms:

• (2S,4Z,7Z)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]trideca-4,7-dien-2-yl N-formyl-L-leucinate
• (2S-(2alpha(1R*,3Z,6Z),3beta))-N-Formyl-L-leucine 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl ester
• <span class="text-smallcaps">L</span>-Leucine, N-formyl-, (1S,3Z,6Z)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-3,6-dodecadien-1-yl ester
• <span class="text-smallcaps">L</span>-Leucine, N-formyl-, (1S,3Z,6Z)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-3,6-dodecadienyl ester
• <span class="text-smallcaps">L</span>-Leucine, N-formyl-, 1-[(3-hexyl-4-oxo-2-oxetanyl)methyl]-3,6-dodecadienyl ester, [2S-[2α(1R*,3Z,6Z),3β]]-
• L-Leucine, N-formyl-, 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl ester, (2S-(2alpha(1R*,3Z,6Z),3beta))-
• L-Leucine, N-formyl-, (1S,3Z,6Z)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-3,6-dodecadienyl ester
• L-Leucine, N-formyl-, (1S,3Z,6Z)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-3,6-dodecadien-1-yl ester
• Lipstatin
• L-Leucine, N-formyl-, 1-[(3-hexyl-4-oxo-2-oxetanyl)methyl]-3,6-dodecadienyl ester, [2S-[2α(1R*,3Z,6Z),3β]]-
• (-)-Lipstatin
• N-Formyl-L-leucine (1S,3Z,6Z)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-3,6-dodecadien-1-yl ester
• L-Leucine, N-formyl-,(1S,3Z,6Z)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-3,6-dodecadien-1-ylester
• Orlistat Tetradehydro Impurity
• high quality Lipstatin
• [(2S,4E,7E)-1-(3-hexyl-4-oxooxetan-2-yl)trideca-4,7-dien-2-yl] (2S)-2-formamido-3-methylpentanoate
• Lipstatin Solution, 100ppm

Lipstatin

CAS: 96829-59-3

Lipstatin is a potent inhibitor of the pancreas lipase. It is reported to be useful in the treatment and/or prevention of obesity and related diseases.

Formula: C₂₉H₄₉NO₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 491.7

Ref: TM-T20441

Lipstatin

CAS: 96829-59-3

Formula: C₂₉H₄₉NO₅

Color and Shape: Pale Yellow Oil To Semi-Solid

Molecular weight: 491.71

Ref: 4Z-L-871

Lipstatin-d3

CAS: 96829-59-3

Formula: C₂₉H₄₆NO₅D₃

Molecular weight: 494.74

Ref: 4Z-L-872

Lipstatin

Controlled Product

CAS: 96829-59-3

Applications Lipstatin, a potent inhibitor of the pancreas lipase, is reported to be useful in the treatment and/or prevention of obesity and related diseases.
References Derosa, G, et al.: Curr. Therap. Res., 63, 621 (2002), Skinner, D., et al.: J. Bacteriol., 177, 183 (1995),

Formula: C₂₉H₄₉NO₅

Color and Shape: Light Yellow Oily

Molecular weight: 491.7

Ref: TR-L468800