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CAS 96861-65-3

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5-(N-methyl-N-isobutyl)-amiloride

Description:
5-(N-methyl-N-isobutyl)-amiloride, identified by its CAS number 96861-65-3, is a chemical compound that belongs to the class of amiloride derivatives. It is primarily recognized for its role as a selective inhibitor of epithelial sodium channels (ENaC), which are crucial in regulating sodium and fluid balance in various tissues, particularly in the kidneys. This compound exhibits properties that make it useful in pharmacological research, particularly in studies related to hypertension and fluid retention. Structurally, it features a substituted amiloride backbone, which contributes to its biological activity. The presence of the N-methyl and N-isobutyl groups enhances its lipophilicity, potentially affecting its absorption and distribution in biological systems. Additionally, 5-(N-methyl-N-isobutyl)-amiloride may exhibit varying degrees of solubility in organic solvents and water, influencing its application in laboratory settings. Overall, this compound serves as a valuable tool in understanding sodium transport mechanisms and developing therapeutic agents targeting related disorders.
Formula:C11H18ClN7O
InChI:InChI=1/C11H18ClN7O/c1-5(2)4-19(3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
SMILES:CC(C)CN(C)c1c(Cl)nc(c(N)n1)C(=NC(=N)N)O
Synonyms:
  • 5-Nmnia
  • Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(methyl(2-methylpropyl)amino)-
  • 3-amino-6-chloro-N-(diaminomethylidene)-5-[methyl(2-methylpropyl)amino]pyrazine-2-carboxamide
  • 5-(N-Methyl-N-isobutyl)amiloride
  • Recombinant Human MIA Protein, His Tag
  • MIBA ( 5-Methoxy-2-iodophenylboronic acid )
  • TIMTEC-BB SBB002968
  • AMILORIDE, 5-(N-METHYL-N-ISOBUTYL)-
  • Melanoma-derived growth regulatory protein
  • CD-RAP
  • See more synonyms
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