CAS 96946-42-8

Cisatracurium besylate

Description:

Cisatracurium besylate is a neuromuscular blocking agent commonly used in anesthesia to facilitate tracheal intubation and provide muscle relaxation during surgical procedures. It is a stereoisomer of atracurium and operates by competitively inhibiting the action of acetylcholine at the neuromuscular junction, leading to muscle paralysis. The substance is characterized by its relatively rapid onset and intermediate duration of action, making it suitable for various surgical settings. Cisatracurium is unique in that it undergoes a process called spontaneous degradation, which allows for its elimination from the body without the need for renal or hepatic function, making it particularly useful in patients with compromised organ function. The besylate salt form enhances its solubility and stability. Additionally, it is important to monitor patients for potential side effects, such as hypotension or allergic reactions, although these are generally rare. Overall, cisatracurium besylate is valued for its efficacy and safety profile in clinical practice.

Formula: C₅₃H₇₂N₂O₁₂·2C₆H₅O₃S

InChI: InChI=1S/C53H72N2O12.C6H6O3S/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6;7-10(8,9)6-4-2-1-3-5-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3;1-5H,(H,7,8,9)/q+2;/p-1/t42-,43-,54-,55-;/m1./s1

InChI key: InChIKey=GLLXELVDCIFBPA-MLPUUEHESA-M

SMILES: C([C@@H]1C=2C(=CC(OC)=C(OC)C2)CC[N@@+]1(CCC(OCCCCCOC(CC[N@+]3(C)[C@H](CC4=CC(OC)=C(OC)C=C4)C=5C(CC3)=CC(OC)=C(OC)C5)=O)=O)C)C6=CC(OC)=C(OC)C=C6.S(=O)(=O)([O-])C1=CC=CC=C1

Synonyms:

• (1R,1'R,2R,2'R)-2,2'-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium dibenzenesulfonate
• (1R,2R)-1-(3,4-dimethoxybenzyl)-2-(3-{[5-({3-[(2R,4R)-4-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium-2(1H)-yl]propanoyl}oxy)pentyl]oxy}-3-oxopropyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium bisbenzenesulfonate
• (1R,2R,1'R,2'R)-2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] bisbenzenesulfonate
• 51W89
• Cis-Atracurium besilate
• Cisatracurium Besilete
• Cisatracurium besylate
• Isoquinolinium, 2,2′-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1R,1′R,2R,2′R)-, benzenesulfonate (1:2)
• Isoquinolinium, 2,2′-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1R,1′R,2R,2′R)-, dibenzenesulfonate
• Isoquinolinium, 2,2′-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, [1R-[1α,2α(1′R*,2′R*)]]-, dibenzenesulfonate
• Nimbex

CISATRACURIUM FOR PEAK IDENTIFICATION CRS

CAS: 96946-42-8

CISATRACURIUM FOR PEAK IDENTIFICATION CRS

Color and Shape: White To Slightly Yellow.

Ref: 41-Y0001768

CISATRACURIUM FOR SYSTEM SUITABILITY CRS

CAS: 96946-42-8

CISATRACURIUM FOR SYSTEM SUITABILITY CRS

Color and Shape: White To Slightly Yellow.

Ref: 41-Y0001767

CISATRACURIUM BESILATE CRS

CAS: 96946-42-8

CISATRACURIUM BESILATE CRS

Color and Shape: Added Modified

Ref: 41-Y0001766

Cisatracurium Besylate

CAS: 96946-42-8

Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused

Formula: C₆₅H₈₂N₂O₁₈S₂

Color and Shape: White Light Yellow Powder

Molecular weight: 1242.50041

Ref: 45-1134118

Cisatracurium besylate

CAS: 96946-42-8

Cisatracurium besylate (51W89) is a nondepolarizing skeletal muscle relaxant for intravenous administration.

Formula: C₅₃H₇₂N₂O₁₂·2C₆H₅O₃S

Purity: 97.89% - 99.85%

Color and Shape: White Or White Powder Category

Molecular weight: 1243.48

Ref: TM-T1459

Cisatracurium

CAS: 96946-42-8

Cisatracurium

Purity: 98%

Molecular weight: 1243.48g/mol

Ref: 54-OR1026891

Cisatracurium besylate

CAS: 96946-42-8

Cisatracurium besylate

Purity: ≥98%

Molecular weight: 1243.48g/mol

Ref: 54-BUP15730

Cis-Atracurium Besylate

CAS: 96946-42-8

Formula: C₅₃H₇₂N₂O₁₂·2C₆H₅O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 929.17 2*157.17

Ref: 4Z-A-751

Atracurium Diiodide (Mixture of Diastereomers)

CAS: 96946-42-8

Formula: C₅₃H₇₂N₂O₁₂·2I

Color and Shape: Pale Yellow Solid

Molecular weight: 929.17 2*126.90

Ref: 4Z-A-7519

Cisatracurium Besylate

CAS: 96946-42-8

Formula: C₆₅H₈₂N₂O₁₈S₂

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 1,243.49

Ref: 3B-C2940

Cisatracurium Besylate (~90%)

Controlled Product

CAS: 96946-42-8

Applications An enantiomer of Atracurium Besylate (A794500). A neuromuscular blocking agent. It could be used in liver transplant patient with safety.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hughes, R., et al.: Br. J. Anaesth., 53, 31 (1981), Basta, S.J., et al.: Anesth. Analog., 61, 723 (1982), Neill, E.A., et al.: Xenobiotica, 12, 203 (1982), Bangsbo, J., et al.: J. Physiol., 422, 539 (1990),

Formula: C₅₃H₇₂N₂O₁₂·2C₆H₅O₃S

Purity: ~90%

Color and Shape: White Solid

Molecular weight: 1243.48

Ref: TR-C496700

Cisatracurium besylate

CAS: 96946-42-8

Purity: 98%

Molecular weight: 1243.49

Ref: 10-F979303

Cisatracurium Iodide

Controlled Product

CAS: 96946-42-8

Formula: C₅₃H₇₂N₂O₁₂•2I

Color and Shape: Neat

Molecular weight: 929.14 + 2(126.91)

Ref: TR-C353935

Cisatracurium besylate

CAS: 96946-42-8

nAChRs nicotinic receptor antagonist; neuromuscular-blocking agent

Formula: C₆₅H₈₂N₂O₁₈S₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 1,243.48 g/mol

Ref: 3D-FC20458