CAS 97068-30-9

Elsamitrucin

Description:

Elsamitrucin, with the CAS number 97068-30-9, is a chemical compound that belongs to the class of antibiotics known as ansamycins. It is primarily derived from the fermentation of certain strains of bacteria, specifically from the genus Micromonospora. Elsamitrucin exhibits potent antibacterial activity, particularly against a range of Gram-positive bacteria, making it a candidate for therapeutic applications in treating bacterial infections. The compound's mechanism of action typically involves the inhibition of bacterial RNA synthesis, which disrupts protein production and ultimately leads to cell death. In addition to its antibacterial properties, Elsamitrucin may also show activity against some tumor cells, indicating potential use in cancer therapy. Its chemical structure features a complex arrangement of rings and functional groups, contributing to its biological activity. As with many antibiotics, the development of resistance is a concern, necessitating ongoing research to understand its efficacy and safety profile in clinical settings.

Formula: C₃₃H₃₅NO₁₃

InChI: InChI=1S/C33H35NO13/c1-11-9-10-16-19-17(11)29(38)46-25-18-14(24(36)21(20(19)25)30(39)44-16)7-6-8-15(18)45-32-28(33(4,40)27(37)13(3)43-32)47-31-22(34)26(41-5)23(35)12(2)42-31/h6-10,12-13,22-23,26-28,31-32,35-37,40H,34H2,1-5H3/t12-,13-,22-,23+,26-,27+,28+,31-,32+,33+/m1/s1

InChI key: InChIKey=MGQRRMONVLMKJL-KWJIQSIXSA-N

SMILES: OC=1C2=C3C=4C(C(=O)OC3=C5C1C=CC=C5O[C@H]6[C@H](O[C@@H]7[C@H](N)[C@@H](OC)[C@@H](O)[C@@H](C)O7)[C@@](C)(O)[C@@H](O)[C@@H](C)O6)=C(C)C=CC4OC2=O

Synonyms:

• Antibiotic BBM 2478A
• Elsamitrucin
• 10-[[2-O-(2-Amino-2,6-dideoxy-3-O-methyl-α-D-galactopyranosyl)-6-deoxy-3-C-methyl-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methylbenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione
• Benzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione, 10-[[2-O-(2-amino-2,6-dideoxy-3-O-methyl-α-D-galactopyranosyl)-6-deoxy-3-C-methyl-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methyl-
• Elsamicin A

Elsamitrucin

CAS: 97068-30-9

Elsamitrucin, a heterocyclic antibiotic, disrupts DNA replication by intercalating into G-C sequences and inhibiting topoisomerases.

Formula: C₃₃H₃₅NO₁₃

Color and Shape: Solid

Molecular weight: 653.63

Ref: TM-T68207