CAS 97148-38-4

Ceftazidime EP Impurity B

Description:

Ceftazidime EP Impurity B, with the CAS number 97148-38-4, is a chemical compound associated with the antibiotic ceftazidime, which belongs to the class of cephalosporins. This impurity is typically a byproduct formed during the synthesis or degradation of ceftazidime. It is characterized by its molecular structure, which includes a beta-lactam ring, a thiazole ring, and various functional groups that influence its chemical behavior. The compound is generally analyzed for its potential impact on the efficacy and safety of ceftazidime formulations. In terms of solubility, it is likely to be soluble in polar solvents, consistent with many cephalosporin derivatives. The presence of impurities like Ceftazidime EP Impurity B is monitored in pharmaceutical formulations to ensure compliance with regulatory standards and to maintain the quality of the active pharmaceutical ingredient. Understanding the characteristics of such impurities is crucial for pharmaceutical development and quality control processes.

Formula: C₂₂H₂₂N₆O₇S₂

Synonyms:

• Ceftazidime impurity 2/Ceftazidime EP Impurity B/E-Ceftazidime/(6R,7R)-7-((E)-2-(2-aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• E-Ceftazidime Ceftazidime Impurity B
• Ceftazidime Impurity B (EP) (E-Ceftazidime)
• (6R,7R)-7-((E)-2-(2-aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• Ceftazidime EP Impurity B

Ceftazidime Dimer 1 Sodium Salt

CAS: 97148-38-4

Formula: C₄₄H₄₁N₁₂O₁₃S₄·Na

Molecular weight: 1074.12 22.99

Ref: 4Z-C-10524

Ceftazidime EP Impurity B

CAS: 97148-38-4

Formula: C₂₂H₂₂N₆O₇S₂

Molecular weight: 546.58

Ref: ST-EA-CP-C12002

E-Ceftazidime

Controlled Product

CAS: 97148-38-4

Applications E-Ceftazidime is an impurity of Ceftazidime Pentahydrate (C244100); which is a third generation cephalosporin antibiotic.
References Brodie, A., et al.: Antimicrob. Agents Chemother., 17, 876 (1980); Richards, D.M., et al.: Drugs, 29, 105 (1985); Abounassif, M.A., et al.: Anal. Profiles Drug Subs., 19, 95 (1990)

Formula: C₂₂H₂₂N₆O₇S₂

Color and Shape: Neat

Molecular weight: 546.58

Ref: TR-C244125

E-Ceftazidime

CAS: 97148-38-4

E-Ceftazidime is a third-generation cephalosporin antibiotic, which is derived from the mold Acremonium. It functions by inhibiting bacterial cell wall synthesis, a crucial component for bacterial survival and replication. This inhibition occurs through the binding to specific penicillin-binding proteins (PBPs) within the bacterial cell wall, thus preventing cross-linking of the peptidoglycan chains, which results in the eventual lysis and death of the bacterial cell.

Formula: C₂₂H₂₂N₆O₇S₂

Purity: Min. 95%

Molecular weight: 546.60 g/mol

Ref: 3D-XDA14838