CAS 97161-97-2

(+)-K 252a

Description:

(+)-K 252a is a naturally occurring alkaloid derived from the plant species *Camptotheca acuminata*. It is known for its potent biological activity, particularly as a selective inhibitor of protein kinase activity, which plays a crucial role in various cellular processes, including cell growth and differentiation. The compound exhibits neuroprotective properties and has been studied for its potential therapeutic applications in neurodegenerative diseases. Chemically, (+)-K 252a features a complex structure that includes a tetracyclic core, contributing to its unique pharmacological profile. Its stereochemistry is significant, as the (+) designation indicates the specific spatial arrangement of atoms that influences its biological interactions. The substance is typically used in research settings to explore signaling pathways and cellular mechanisms, and it is important to handle it with care due to its bioactive nature. As with many alkaloids, further studies are ongoing to fully elucidate its mechanisms of action and potential clinical applications.

Formula: C₂₇H₂₁N₃O₅

InChI: InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1

InChI key: InChIKey=KOZFSFOOLUUIGY-SOLYNIJKSA-N

SMILES: C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@]2(C(OC)=O)O)[H])=CC=CC8

Synonyms:

• (+)-Antibiotic K 252a
• (+)-Antibiotic SF 2370
• (+)-K 252a
• (+)-Sf 2370
• 6,9-epoxy-15H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-7-carboxylic acid, 6,7,8,9,16,17-hexahydro-7-hydroxy-6-methyl-15-oxo-, methyl ester, (6R,7S,9S)-
• 9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R)-
• 9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, [9S-(9α,10β,12α)]-
• K 252
• K 252a Nocardiopsis sp.
• Protein kinase inhibitor K252a