CAS 97203-04-8

7-Dehydroxy Buprenorphine (Buprenorphine IMpurity F)

Description:

7-Dehydroxy Buprenorphine, also known as Buprenorphine Impurity F, is a chemical compound with the CAS number 97203-04-8. It is a derivative of buprenorphine, an opioid used primarily for pain management and in the treatment of opioid addiction. This impurity is characterized by the presence of a hydroxyl group at the 7-position of the buprenorphine structure, which alters its pharmacological properties compared to the parent compound. The molecular structure of 7-Dehydroxy Buprenorphine contributes to its potential activity and interactions within biological systems, although it is typically present in trace amounts in pharmaceutical formulations. Its identification and quantification are important for quality control in the production of buprenorphine to ensure safety and efficacy. As with many opioid derivatives, it may exhibit varying degrees of affinity for opioid receptors, influencing its therapeutic and side effect profiles. Proper handling and analysis of this compound are essential in pharmaceutical contexts to mitigate any potential risks associated with impurities.

Formula: C₂₉H₃₉NO₃

Synonyms:

• 17-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methoxy-7alpha-[1-(1,1-dimethylethyl)ethenyl]-6alpha,14-ethano-14alpha-morphinan-3-ol
• (5α,7α)-17-(CyclopropylMethyl)-7-(2,2-diMethyl-1-Methylenepropyl)-4,5-epoxy-18,19-dihydro-6-Methoxy-6,14-ethenoMorphinan-3-ol
• 7-Dehydroxy Buprenorphine
• 7-Dehydroxy Buprenorphine (1.0mg/ml in Acetonitrile)
• 6,14-Ethenomorphinan-3-ol, 17-(cyclopropylmethyl)-7-(2,2-dimethyl-1-methylenepropyl)-4,5-epoxy-18,19-dihydro-6-methoxy-, (5α,7α)- (9CI)
• *Tramadol Impurity 7-d6 ((+)-Tramadol-d6 Hydrochloride)
• PubChem ID: 71315359
• (Buprenorphine IMpurity F)
• Buprenorphine IMpurity F
• LONIMXCUBDTSNU-MHZLKSCOSA-N

17-(Cyclopropylmethyl)-4,5α-epoxy-6-methoxy-7α-[1-(1,1-dimethylethyl)ethenyl]-6α,14-ethano-14α-morphinan-3-ol

Controlled Product

CAS: 97203-04-8

Color and Shape: Neat

Ref: 86-MM1237.06

7-Dehydroxy Buprenorphine (Buprenorphine Impurity F)

Controlled Product

CAS: 97203-04-8

Formula: C₂₉H₃₉NO₃

Color and Shape: White To Off-White

Molecular weight: 449.62

Ref: TR-D230635

7-Dehydroxy Buprenorphine (1.0mg/ml in Acetonitrile)

Controlled Product

CAS: 97203-04-8

Formula: C₂₉H₃₉NO₃

Color and Shape: Single Solution

Molecular weight: 449.62

Ref: TR-KIT3950

7-Dehydroxy buprenorphine(buprenorphine impurity F)

Controlled Product

CAS: 97203-04-8

7-Dehydroxy buprenorphine is a drug product that is used in the synthesis of buprenorphine. It is also an impurity found in buprenorphine and its metabolite, norbuprenorphine. 7-Dehydroxy buprenorphine is a synthetic substance with no known natural sources and has been shown to bind to proteins such as albumin or alpha-1-acid glycoprotein. 7-Dehydroxy buprenorphine has been found to be an impurity in both buprenorphine and norbuprenorphine. It has not been identified as a major contributor to the pharmacological effects of these drugs, but it may contribute to their toxicity. The compound has been shown to be a potent inhibitor of human liver microsomal cytochrome P450 (CYP) 3A4 activity at concentrations of 1 micromolar or less, which may result in decreased metabolism of other co

Formula: C₂₉H₃₉NO₃

Purity: Min. 95%

Molecular weight: 449.62 g/mol

Ref: 3D-ID20968