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CAS 976-70-5

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Pregn-4-ene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, (17α)-

Description:
Pregn-4-ene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, (17α)-, commonly known as 17α-hydroxyprogesterone caproate, is a synthetic derivative of progesterone. It is characterized by its steroidal structure, which includes a pregnane backbone with specific functional groups that confer its biological activity. This compound is typically used in hormone replacement therapy and has applications in obstetrics to prevent preterm birth. It exhibits progestational effects, influencing the menstrual cycle and maintaining pregnancy. The γ-lactone structure contributes to its stability and bioavailability. In terms of solubility, it is generally lipophilic, allowing for effective absorption when administered via intramuscular injection. The compound's pharmacokinetics involve metabolism primarily in the liver, leading to various metabolites that may also exhibit hormonal activity. Safety and efficacy profiles are well-documented, making it a valuable therapeutic agent in clinical settings. As with any hormone therapy, monitoring for potential side effects is essential during treatment.
Formula:C22H30O3
InChI:InChI=1S/C22H30O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h13,16-18H,3-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1
InChI key:InChIKey=UWBICEKKOYXZRG-WNHSNXHDSA-N
SMILES:C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(CC4)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3
Synonyms:
  • (8R,9S,10R,13S,14S,17R)-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
  • 17-alpha-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone
  • 17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone
  • 17β-Hydroxy-3-oxopregn-4-en-21-carboxylic acid γ-lactone
  • 20-Spirox-4-ene-3,20-dione
  • 3-(3-Oxo-17-beta-hydroxy-4-androsten-17-alpha-yl)propionic acid gamma-lactone
  • 3-(3-Oxo-17β-hydroxy-4-androsten-17-yl)propionic acid γ-lactone
  • 3-(3-Oxo-17β-hydroxyandrost-4-en-17α-yl)propiolactone
  • 3-Oxopregn-4-ene-21,17alpha-carbolactone
  • 3′-(3-Oxo-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone
  • See more synonyms
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