CAS 97682-44-5

Irinotecan

Description:

Irinotecan is a chemotherapeutic agent primarily used in the treatment of colorectal cancer. It is classified as a topoisomerase I inhibitor, which interferes with DNA replication and transcription, ultimately leading to cancer cell death. The compound is a semi-synthetic derivative of camptothecin, derived from the bark of the Camptotheca acuminata tree. Irinotecan is administered intravenously and is often used in combination with other chemotherapy agents to enhance its efficacy. Its mechanism of action involves the stabilization of the topoisomerase I-DNA complex, preventing the re-ligation of DNA strands and causing DNA damage. The drug is known for its side effects, which can include diarrhea, nausea, vomiting, and myelosuppression, necessitating careful monitoring during treatment. Pharmacokinetically, irinotecan is metabolized in the liver, primarily by the enzyme UGT1A1, and its active metabolite, SN-38, is significantly more potent than the parent compound. Overall, irinotecan plays a crucial role in modern oncology, particularly for patients with advanced or metastatic colorectal cancer.

Formula: C₃₃H₃₈N₄O₆

InChI: InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1

InChI key: InChIKey=UWKQSNNFCGGAFS-XIFFEERXSA-N

SMILES: C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(OC(=O)N6CCC(CC6)N7CCCCC7)=CC5

Synonyms:

• (19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
• (S)-4,11-Diethyl-4-Hydroxy-3,14-Dioxo-3,4,12,14-Tetrahydro-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinolin-9-Yl [1,4'-Bipiperidine]-1'-Carboxylate
• 1,4'-Bipiperidine-1'-Carboxylic Acid (S)-4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinolin-9-Yl Ester
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline, [1,4′-bipiperidine]-1′-carboxylic acid deriv.
• Irinophore C
• Irinotecan Free Base
• Irinotecan base
• Irinotecan lactone
• Irinotecan mylan
• [1,4′-Bipiperidine]-1′-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester
• [1,4′-Bipiperidine]-1′-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, (S)-
• (+)-Irinotecan

Irinotecan Hydrochloride Trihydrate

CAS: 100286-90-6, 136572-09-3, 97682-44-5

Formula: C₃₃H₃₈N₄O₆·HCl·3H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 677.20

Ref: 3B-I0714

1,4'-bipiperidine-1'-carboxylic acid (s)-4,11-diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester

CAS: 97682-44-5

Formula: C₃₃H₃₈N₄O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 586.6780

Ref: IN-DA0035ZK

Irinotecan

CAS: 97682-44-5

Formula: C₃₃H₃₈N₄O₆

Molecular weight: 586.68

Ref: 7W-GP2320

(+)-Irinotecan

CAS: 97682-44-5

(+)-Irinotecan

Purity: 98%

Molecular weight: 586.68g/mol

Ref: 54-OR1026492

Irinotecan

CAS: 97682-44-5

Irinotecan

Purity: ≥98%

Molecular weight: 586.68g/mol

Ref: 54-BUP15721

Irinotecan

CAS: 97682-44-5

Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.

Formula: C₃₃H₃₈N₄O₆

Purity: 98% - 99.92%

Color and Shape: Solid

Molecular weight: 586.68

Ref: TM-T6228

(+)-Irinotecan

Controlled Product

CAS: 97682-44-5

Applications (+)-Irinotecan is a Topo I inhibitor.

Formula: C₃₃H₃₈N₄O₆

Color and Shape: Neat

Molecular weight: 586.68

Ref: TR-I767523

Irinotecan

CAS: 97682-44-5

Inhibitor of DNA topoisomerase I

Formula: C₃₃H₃₈N₄O₆

Purity: Min. 98 Area-%

Color and Shape: Beige Powder

Molecular weight: 586.68 g/mol

Ref: 3D-FI33814