CAS 97682-44-5
:Irinotecan
Description:
Irinotecan is a chemotherapeutic agent primarily used in the treatment of colorectal cancer. It is classified as a topoisomerase I inhibitor, which interferes with DNA replication and transcription, ultimately leading to cancer cell death. The compound is a semi-synthetic derivative of camptothecin, derived from the bark of the Camptotheca acuminata tree. Irinotecan is administered intravenously and is often used in combination with other chemotherapy agents to enhance its efficacy. Its mechanism of action involves the stabilization of the topoisomerase I-DNA complex, preventing the re-ligation of DNA strands and causing DNA damage. The drug is known for its side effects, which can include diarrhea, nausea, vomiting, and myelosuppression, necessitating careful monitoring during treatment. Pharmacokinetically, irinotecan is metabolized in the liver, primarily by the enzyme UGT1A1, and its active metabolite, SN-38, is significantly more potent than the parent compound. Overall, irinotecan plays a crucial role in modern oncology, particularly for patients with advanced or metastatic colorectal cancer.
Formula:C33H38N4O6
InChI:InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1
InChI key:InChIKey=UWKQSNNFCGGAFS-XIFFEERXSA-N
SMILES:C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(OC(=O)N6CCC(CC6)N7CCCCC7)=CC5
Synonyms:- (19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
- (S)-4,11-Diethyl-4-Hydroxy-3,14-Dioxo-3,4,12,14-Tetrahydro-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinolin-9-Yl [1,4'-Bipiperidine]-1'-Carboxylate
- 1,4'-Bipiperidine-1'-Carboxylic Acid (S)-4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinolin-9-Yl Ester
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline, [1,4′-bipiperidine]-1′-carboxylic acid deriv.
- Irinophore C
- Irinotecan Free Base
- Irinotecan base
- Irinotecan lactone
- Irinotecan mylan
- [1,4′-Bipiperidine]-1′-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester
- [1,4′-Bipiperidine]-1′-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, (S)-
- (+)-Irinotecan
- See more synonyms
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Found 11 products.
1,4'-bipiperidine-1'-carboxylic acid (s)-4,11-diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester
CAS:Formula:C33H38N4O6Purity:98%Color and Shape:SolidMolecular weight:586.6780Irinotecan (Standard)
CAS:Irinotecan (Standard) is a reference standard for research and analysis in studies involving Irinotecan. Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting in double-stranded DNA breaks and cell death.Formula:C33H38N4O6Color and Shape:SolidMolecular weight:586.68Irinotecan
CAS:Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.Formula:C33H38N4O6Purity:98% - 99.92%Color and Shape:SolidMolecular weight:586.68(+)-Irinotecan
CAS:Controlled ProductApplications (+)-Irinotecan is a Topo I inhibitor.
Formula:C33H38N4O6Color and Shape:NeatMolecular weight:586.68Irinotecan
CAS:Inhibitor of DNA topoisomerase IFormula:C33H38N4O6Purity:Min. 98 Area-%Color and Shape:Beige PowderMolecular weight:586.68 g/molIrinotecan
CAS:(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylateFormula:C33H38N4O6Purity:98%Molecular weight:586.68
