CAS 97952-36-8

5′-Guanylic acid, monoanhydride with phosphorothioic acid, trilithium salt

Description:

5′-Guanylic acid, monoanhydride with phosphorothioic acid, trilithium salt, identified by CAS number 97952-36-8, is a chemical compound that combines elements of nucleic acid chemistry and phosphorothioate chemistry. This substance is a derivative of guanylic acid, which is a nucleotide that plays a crucial role in cellular signaling and energy transfer. The presence of phosphorothioic acid indicates that it contains a sulfur atom in place of one of the oxygen atoms in the phosphate group, which can enhance the stability of the molecule against enzymatic degradation. The trilithium salt form suggests that the compound is neutralized with lithium ions, which can influence its solubility and biological activity. Typically, such compounds are of interest in biochemical research, particularly in the development of therapeutic agents or as tools in molecular biology, due to their potential to modulate biological processes. The specific characteristics, such as solubility, stability, and reactivity, would depend on the molecular structure and the conditions under which the compound is studied.

Formula: C₁₀H₁₅N₅O₁₀P₂S·3Li

InChI: InChI=1S/C10H15N5O10P2S.3Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(24-9)1-23-26(19,20)25-27(21,22)28;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H2,21,22,28)(H3,11,13,14,18);;;/t3-,5-,6-,9-;;;/m1.../s1

InChI key: InChIKey=UVNVXNFQSINEHH-CYCLDIHTSA-N

SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(OP(=O)(O)S)(=O)O)[C@H]1O.[Li]

Synonyms:

• 5′-Guanylic acid, monoanhydride with phosphorothioic acid, trilithium salt
• Guanosine 5-O-(2-Thiodiphosphate), Trilithium Salt
• Guanosine 5-[beta-thio]diphosphate trilithium salt

5'-Guanylic acid, monoanhydride with phosphorothioic acid, trilithium salt

CAS: 97952-36-8

Formula: C₁₀H₁₂Li₃N₅O₁₀P₂S

Purity: 85%

Color and Shape: Liquid

Molecular weight: 477.0653

Ref: IN-DA01H5ET

Guanosine 5''-O-(2-thiodiphosphate); trilithium Salt

CAS: 97952-36-8

Formula: C₁₀H₁₂Li₃N₅O₁₀P₂S

Purity: (HPLC) ≥ 85.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 477.07

Ref: 7W-GN7747

Guanosine 5'-O-(2-thiodiphosphate) trilithium salt

CAS: 97952-36-8

Guanosine 5'-O-(2-thiodiphosphate) trilithium salt (GTPTS) is a membrane-permeable molecule that hyperpolarizes cells by inhibiting the movement of ions through the cell membrane. GTPTS is activated by extracellular calcium and potassium ions, which are involved in signal transduction pathways. It has been shown to inhibit the release of neurotransmitters, such as acetylcholine, dopamine, serotonin, and norepinephrine. GTPTS also blocks voltage-gated sodium channels, which leads to a reduction in neuronal excitability. The drug has been shown to have analgesic effects in animal models of pain and can be used to treat chronic pain due to nerve damage.

Formula: C₁₀H₁₂Li₃N₅O₁₀P₂S

Purity: Min. 85 Area-%

Color and Shape: Powder

Molecular weight: 477.06 g/mol

Ref: 3D-NG09615

Guanosine 5’-O-(2-Thiodiphosphate) Trilithium Salt

Controlled Product

CAS: 97952-36-8

Applications Guanosine 5’-O-(2-Thiodiphosphate) Trilithium Salt is a GDP analog that inhibits G-protein activation.
References Silk, S.T., et al.: J. Biol. Chem., 264, 21466-9 (1989); Burch, R.M., et al.: Proceedings of the National Academy of Sciences of the United States of America, 84, 6374-8 (1987); Gilman, A.G., et al.: Annual review of biochemistry, 56, 615-49 (1987);

Formula: C₁₀H₁₂N₅O₁₀P₂S·3Li

Color and Shape: Neat

Molecular weight: 477.065

Ref: TR-G838708