CAS 98-74-8

Benzenesulfonyl chloride, 4-nitro-

Description:

4-Nitrobenzenesulfonyl chloride, with the CAS number 98-74-8, is an aromatic sulfonyl chloride characterized by the presence of a nitro group attached to a benzene ring that is also bonded to a sulfonyl chloride functional group. This compound typically appears as a yellow to brown solid and is known for its reactivity, particularly in nucleophilic substitution reactions. The sulfonyl chloride group makes it a potent electrophile, allowing it to react with various nucleophiles, including amines and alcohols, to form sulfonamides and sulfonate esters, respectively. It is soluble in organic solvents such as dichloromethane and ether but is generally insoluble in water. Due to its reactive nature, 4-nitrobenzenesulfonyl chloride is often used in organic synthesis, particularly in the preparation of sulfonamide derivatives and other functionalized compounds. However, it should be handled with care, as it can be corrosive and poses health hazards upon exposure. Proper safety precautions, including the use of personal protective equipment, are essential when working with this chemical.

Formula: C₆H₄ClNO₄S

InChI: InChI=1/C6H4ClNO4S/c7-13(11,12)6-3-1-5(2-4-6)8(9)10/h1-4H

InChI key: InChIKey=JXRGUPLJCCDGKG-UHFFFAOYSA-N

SMILES: S(Cl)(=O)(=O)C1=CC=C(N(=O)=O)C=C1

Synonyms:

• 4-Nitrobenzene-1-sulfonyl chloride
• 4-Nitrobenzenesulfonic acid chloride
• 4-Nitrobenzenesulfonyl chloride
• 4-Nitrobenzenesulphonyl Chloride
• 4-Nitrobenzolsulfonylchlorid
• 4-Nitrophenyl-1-sulfonyl chloride
• 4-Nitrophenylsulfonyl chloride
• Benzenesulfonyl chloride, p-nitro-
• Chlorure De 4-Nitrobenzenesulfonyle
• Cloruro De 4-Nitrobencenosulfonilo
• Nosyl chloride
• Nsc 13065
• Nsc 9572
• p-Nitrobenzenesulfonyl chloride
• p-Nitrophenylsulfonyl chloride
• p-Nosyl chloride
• 4-nitro-benzenesulfonylchlorid
• p-Nitrobenzene sulphonyl chloride
• Benzenesulfonyl chloride, 4-nitro-
• p-nitrobenzene sulfonyl chloride
• Benzenesulfonylchloride,4-nitro-
• Benzenesulfonyl chloride, 4-nitro-
• 4-Nitrophenylsulfonylchloride
• 1-(Chlorosulfonyl)-4-nitrobenzene
• 4-NITROBENZENE-1-SULPHONYL CHLORIDE
• Nosylchloride
• 4-Nitrobenzenesulfonylchloride,98%
• 4-NITROBENZENESULFONYL CHLORIDE, TECH., 90%

4-Nitrobenzenesulfonyl chloride, 97%

CAS: 98-74-8

4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective -glucosylation of partially protected

Formula: C₆H₄ClNO₄S

Purity: 97%

Color and Shape: Powder or crystalline powder, White to cream or yellow to brown

Molecular weight: 221.62

Ref: 02-A18512

4-Nitrobenzenesulphonyl chloride

CAS: 98-74-8

4-Nitrobenzenesulphonyl chloride

Formula: C₆H₄ClNO₄S

Purity: ≥95%

Color and Shape: faint yellow to light yellow crystalline solid

Molecular weight: 221.61826g/mol

Ref: 54-OR28919

4-Nitrobenzenesulfonyl chloride

CAS: 98-74-8

Formula: C₆H₄ClNO₄S

Purity: 97.0%

Color and Shape: Solid, Powder or Crystalline Powder or Solid

Molecular weight: 221.61

Ref: 10-F044651

4-Nitrobenzenesulfonyl Chloride

CAS: 98-74-8

Formula: C₆H₄ClNO₄S

Purity: >98.0%(GC)(T)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 221.61

Ref: 3B-N0144

4-Nitrobenzenesulfonyl chloride

CAS: 98-74-8

4-Nitrobenzenesulfonyl chloride is a versatile chemical compound. As a reagent in organic synthesis, it plays a crucial role in the preparation of pharmaceuticals, iminosugars, and oligosaccharides. Its ability to facilitate alpha-glucosylation makes it an essential component in the synthesis of complex carbohydrates. 4-Nitrobenzenesulfonyl chloride is also utilized in the preparation of N-nosyl-alpha-amino acids, which are essential building blocks in peptide synthesis. Additionally, it is widely used in the production of dyes and pigments.

Formula: C₆H₄ClNO₄S

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 221.62 g/mol

Ref: 3D-FN03618

4-Nitrobenzenesulfonyl Chloride

Controlled Product

CAS: 98-74-8

Stability Moisture Sensitive
Applications 4-Nitrobenzenesulfonyl Chloride is used in the preparation of N-Nosyl-α-amino acid for peptide synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Leggio, A. et al.: Tetrahedron, 63, 8164 (2007); Di Gioia, M.L. et al.: J. Org. Chem., 68, 7416 (2003);

Formula: C₆H₄ClNO₄S

Color and Shape: Neat

Molecular weight: 221.62

Ref: TR-N493535

Darunavir Impurity 21

CAS: 98-74-8

Formula: C₆H₄ClNO₄S

Molecular weight: 221.61

Ref: ST-EA-CP-D70043