CAS 980-21-2

Dityrosine

Description:

Dityrosine is a dipeptide formed by the oxidative coupling of two tyrosine molecules, characterized by its unique structure that includes two tyrosine residues linked by a covalent bond. It is commonly found in proteins and is significant in the study of protein structure and function, particularly in the context of oxidative stress and aging. Dityrosine exhibits fluorescence properties, making it useful as a biomarker for oxidative damage in biological systems. The compound is soluble in water and exhibits stability under various pH conditions, although it can be sensitive to extreme temperatures and oxidative environments. Its formation is often associated with the cross-linking of proteins, which can affect the mechanical properties and stability of protein structures. Dityrosine is also of interest in various fields, including biochemistry and materials science, due to its potential applications in the development of biomaterials and as an indicator of protein misfolding or aggregation in diseases.

Formula: C₁₈H₂₀N₂O₆

InChI: InChI=1/C18H20N2O6/c19-13(17(23)24)7-9-1-3-15(21)11(5-9)12-6-10(2-4-16(12)22)8-14(20)18(25)26/h1-6,13-14,21-22H,7-8,19-20H2,(H,23,24)(H,25,26)

InChI key: InChIKey=OQALFHMKVSJFRR-UHFFFAOYSA-N

SMILES: OC=1C(=CC(CC(C(O)=O)N)=CC1)C2=CC(CC(C(O)=O)N)=CC=C2O

Synonyms:

• [1,1′-Biphenyl]-3,3′-dipropanoic acid, α3,α3′-diamino-6,6′-dihydroxy-
• 3,3′-Bityrosine
• [1,1′-Biphenyl]-3,3′-dipropanoic acid, α,α′-diamino-6,6′-dihydroxy-
• 3,3′-Biphenyldialanine, 6,6′-dihydroxy-
• 3,3′-Biphenyldipropionic acid, α,α′-diamino-6,6′-dihydroxy-
• Dityrosine
• 2-amino-3-[3-[5-(2-amino-2-carboxy-ethyl)-2-hydroxy-phenyl]-4-hydroxy-phenyl]propanoic acid
• 2-amino-3-[3-[5-(2-amino-3-hydroxy-3-oxopropyl)-2-hydroxyphenyl]-4-hydroxyphenyl]propanoic acid
• [1,1'-Biphenyl]-3,3'-dipropanoicacid, a3,a3'-diaMino-6,6'-dihydroxy-
• 2-Amino-3-[5'-(2-amino-2-carboxy-ethyl)-6,2'-dihydroxy-biphenyl-3-yl]-propionic acid

3,3'-(6,6'-Dihydroxy-[1,1'-biphenyl]-3,3'-diyl)bis(2-aminopropanoic acid)

CAS: 980-21-2

3,3'-(6,6'-Dihydroxy-[1,1'-biphenyl]-3,3'-diyl)bis(2-aminopropanoic acid)

Purity: 95%

Molecular weight: 360.37g/mol

Ref: 54-OR1070300

Dityrosine Dihydrochloride (Mixture of Diastereomers)

Controlled Product

CAS: 980-21-2

Applications Dityrosine (DY), a tyrosine dimer formed by 3,3’-biaryl bond formation can be used as a biomarker to detect oxidative protein damage and selective proteolysis. Fluorescence intensity decays of Dityrosine are generally characterized by two decay components, one with a lifetime in the range of 150 to 800 ps and another between 2.5 and 4.5 ns.
References Libertini, L., et al.: Biophys. J., 47, 765 (1985), Huggins, T., et al.: J. Biol. Chem., 268, 12341 (1993), Malencik, D., et al.: Biochemistry, 35, 4375 (1996),

Formula: C₁₈H₂₀N₂O₆•2HCl

Color and Shape: Neat

Molecular weight: 433.28

Ref: TR-D494205

Dityrosine (Mixture of Diastereomers)

CAS: 980-21-2

Formula: C₁₈H₂₀N₂O₆

Molecular weight: 360.4

Ref: ST-EA-CP-D172001