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CAS 98048-97-6

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Fosinopril

Description:
Fosinopril is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to inhibit the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure. Fosinopril is unique among ACE inhibitors due to its dual elimination pathway, being excreted both renally and hepatically, which can be advantageous in patients with varying degrees of kidney function. The substance is typically administered in its prodrug form, which is converted to its active metabolite in the body. Fosinopril is known for its relatively long half-life, allowing for once-daily dosing. Common side effects may include cough, hyperkalemia, and hypotension, similar to other ACE inhibitors. Its chemical structure includes a phosphinic acid group, which contributes to its pharmacological activity. Overall, Fosinopril is an effective medication for managing cardiovascular conditions, with a well-established safety profile when used appropriately.
Formula:C30H46NO7P
InChI:InChI=1S/C30H46NO7P/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35)/t25-,26+,30+,39-/m1/s1
InChI key:InChIKey=BIDNLKIUORFRQP-XYGFDPSESA-N
SMILES:C(CP(O[C@H](OC(CC)=O)[C@@H](C)C)(CCCCC1=CC=CC=C1)=O)(=O)N2C[C@@H](C[C@H]2C(O)=O)[C@H]3CCCCC3
Synonyms:
  • (4S)-4-Cyclohexyl-1-[2-[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-<span class="text-smallcaps">L</span>-proline
  • (4S)-4-cyclohexyl-1-({[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)-L-proline
  • 4-Cyclohexyl-1-[2-[(2-Methyl-1-Propanoyloxy-Propoxy)-(4-Phenylbutyl)Phosphoryl]Acetyl]
  • <span class="text-smallcaps">L</span>-Proline, 4-cyclohexyl-1-[2-[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-, (4S)-
  • <span class="text-smallcaps">L</span>-Proline, 4-cyclohexyl-1-[[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-, (4S)-
  • <span class="text-smallcaps">L</span>-Proline, 4-cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-, [1[S*(R*)],2α,4β]-
  • Fosenopril
  • Fozitec
  • L-Proline, 4-cyclohexyl-1-[2-[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-, (4S)-
  • L-Proline, 4-cyclohexyl-1-[[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-, (4S)-
  • See more synonyms
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Found 6 products.