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CAS 982-57-0

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Chloramphenicol sodium succinate

Description:
Chloramphenicol sodium succinate is a prodrug form of chloramphenicol, an antibiotic that is effective against a wide range of bacteria. This compound is characterized by its sodium salt form, which enhances its solubility in water, making it suitable for intravenous administration. Chloramphenicol itself is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. The sodium succinate moiety improves its pharmacokinetic properties, allowing for better absorption and distribution in the body. Chloramphenicol sodium succinate is typically used in clinical settings for the treatment of serious infections, particularly when other antibiotics are ineffective or contraindicated. It is important to note that chloramphenicol can cause serious side effects, including bone marrow suppression and aplastic anemia, which necessitates careful monitoring during treatment. The compound is also subject to regulatory scrutiny due to its potential for toxicity and the availability of safer alternatives. Overall, chloramphenicol sodium succinate is a valuable therapeutic agent in specific clinical scenarios, despite its associated risks.
Formula:C15H16Cl2N2O8·Na
InChI:InChI=1S/C15H16Cl2N2O8.Na/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26;/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21);/t10-,13-;/m1./s1
InChI key:InChIKey=OQAWGHRXAVKAIG-HTMVYDOJSA-N
SMILES:[C@@H]([C@H](O)C1=CC=C(N(=O)=O)C=C1)(NC(C(Cl)Cl)=O)COC(CCC(O)=O)=O.[Na]
Synonyms:
  • <span class="text-smallcaps">D</span>-Chloramphenicol sodium succinate
  • Betamicetin
  • Butanedioic acid, 1-[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester, sodium salt (1:1)
  • Butanedioic acid, mono[(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester, monosodium salt
  • Butanedioic acid, mono[2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester, monosodium salt, [R-(R*,R*)]-
  • Chloramphenicol Monosuccinate Sodium Salt
  • Chloramphenicol Sodium Succinate
  • Chloramphenicol sodium hemisuccinate
  • Chloramphenicol sodium monosuccinate
  • Chloramphenicol succinate sodium
  • See more synonyms
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