CAS 98418-47-4

Metoprolol succinate

Description:

Metoprolol succinate is a selective beta-1 adrenergic receptor blocker primarily used in the treatment of hypertension, heart failure, and certain types of arrhythmias. It is a white to off-white crystalline powder that is soluble in water and exhibits good oral bioavailability. The substance is a succinate salt of metoprolol, which enhances its pharmacokinetic properties, allowing for extended-release formulations. Metoprolol succinate works by blocking the effects of adrenaline on the heart, leading to decreased heart rate and contractility, ultimately reducing blood pressure and myocardial oxygen demand. Its chemical structure includes a phenolic ring and a side chain that contributes to its beta-1 selectivity. The drug is typically administered orally and is known for its relatively favorable side effect profile, although it may still cause fatigue, dizziness, or bradycardia in some patients. As with any medication, it is important to use metoprolol succinate under medical supervision to monitor for potential interactions and contraindications.

Formula: C₁₅H₂₅NO₃·C₄H₆O₄

InChI: InChI=1/2C15H25NO3.C4H6O4/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-3(6)1-2-4(7)8/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

InChI key: InChIKey=ZBOQQGAVXCUYJM-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)C)O)C1=CC=C(CCOC)C=C1.C(CC(O)=O)C(O)=O

Synonyms:

• 1-[4-(2-Methoxyethyl)Phenoxy]-3-(Propan-2-Ylamino)Propan-2-Ol Butanedioate (2:1)
• 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (±)-, butanedioate (2:1) (salt)
• Beloc-Zok
• Betaloc CR
• Betaloc Zok
• Betazok
• Butanedioic acid, compd. with (±)-1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (1:2)
• H 93/26 succinate
• Metoprolol Succinate
• Seloken-Zok
• Selozok
• Toprol XL
• Metoprolol Succinate (200 mg)F0C4150.998mg/mg(ai)
• rolol succinate
• Metoprolol Succinate (200 mg)
• Metoprolol Succinate (ToprolX)

Metoprolol Succinate

CAS: 98418-47-4

Aromatic drugs of amino-alcohols, other than those contg > one kind of oxygen function, their ethers and esters; salts thereof, nesoi

Formula: (C₁₅H₂₅NO₃)₂·C₄H₆O₄

Color and Shape: White Off-White Powder

Molecular weight: 534.36689

Ref: 45-1441298

Butanedioic acid, compd. with (±)-1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (1:2)

CAS: 98418-47-4

Formula: C₃₄H₅₆N₂O₁₀

Purity: 99%

Color and Shape: Solid

Molecular weight: 652.8158

Ref: IN-DA0036VK

Metoprolol succinate, USP grade

CAS: 98418-47-4

Formula: C₃₀H₅₀N₂O₆·C₄H₆O₄

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: White to off-white powder

Molecular weight: 652.82

Ref: 7W-GX8301

Metoprolol Succinate

CAS: 98418-47-4

Color and Shape: Neat

Ref: 86-MM0279.00

Metoprolol Succinate

CAS: 98418-47-4

Formula: C₃₀H₅₀N₂O₆·C₄H₆O₄

Molecular weight: 652.82

Ref: 4Z-M-0836

Metoprolol Succinate

CAS: 98418-47-4

Formula: C₁₅H₂₅NO₃(C₄H₆O₄)

Molecular weight: 267.4 : 1/2(118.1)

Ref: ST-EA-CP-M17024

Metoprolol Succinate

Controlled Product

CAS: 98418-47-4

Stability Hygroscopic
Applications Metoprolol Succinate is used in the treatment of patients suffering from chronic heart failure, as well as to treat blood pressure from mild hypertension. β-adrenoceptor antagonist or β-blocker.
References Yazici, H. et al Sci. World J., 608683/1, 7 (2013); Studinger, P. et al.: J. Clin. Hyper., 15, 910 (2013);

Formula: C₁₅H₂₅NO₃·C₄H₆O₄

Color and Shape: Neat

Molecular weight: 652.82

Ref: TR-M338825

Metroprolol succinate

Controlled Product

CAS: 98418-47-4

Metroprolol succinate is a prodrug of metoprolol. It is used for the treatment of high-sensitivity c-reactive protein, which is an inflammatory marker that indicates the presence and severity of atherosclerosis. Metoprolol succinate also has anti-inflammatory properties and can be used to treat cardiac disorders such as congestive heart failure. The drug inhibits the growth factor-β1 pathway in cardiac cells, which may be due to its ability to inhibit cellular proliferation by inducing apoptosis. This drug also has a protective effect on the skeleton, preventing bone loss and osteoporosis. Metroprolol succinate can be used in sample preparation for hydrochloric acid digestion or particle size analysis.

Formula: (C₁₅H₂₅NO₃)₂•C₄H₆O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 652.82 g/mol

Ref: 3D-FM32353

Metoprolol Succinate

CAS: 98418-47-4

Color and Shape: Neat

Ref: 61-FOR0279.00