CAS 98651-66-2

Halobetasol

Description:

Halobetasol is a synthetic corticosteroid primarily used for its anti-inflammatory and immunosuppressive properties, making it effective in treating various dermatological conditions such as psoriasis and eczema. It is characterized by its high potency, which allows for effective management of inflammatory skin disorders with minimal application. Halobetasol functions by inhibiting the release of inflammatory mediators and reducing the proliferation of skin cells. The substance is typically formulated as a topical ointment, cream, or lotion, and is applied directly to the affected area. Its chemical structure includes a halogen atom, which contributes to its enhanced efficacy compared to other corticosteroids. While effective, the use of Halobetasol should be monitored due to potential side effects, including skin thinning and systemic absorption, especially with prolonged use or application over large areas. As with any medication, it is essential to follow prescribed guidelines to minimize risks and maximize therapeutic benefits.

Formula: C₂₂H₂₇ClF₂O₄

InChI: InChI=1S/C22H27ClF2O4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1

InChI key: InChIKey=LEHFPXVYPMWYQD-XHIJKXOTSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CCl)=O)(O)[C@@H](C)C3)[H])(C[C@H](F)C=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (6α,11β,16β)-21-Chloro-6,9-difluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
• Halobetasol
• Pregna-1,4-diene-3,20-dione, 21-chloro-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6α,11β,16β)-
• Unii-9P6159Hm7T
• Ulobetasol
• HALOBETASOL PROPIOTE
• Ulobetasol [inn]
• 21-Chloro Diflorasone
• (6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• Diflorasone 21-Chloro

Halobetasol

CAS: 98651-66-2

Formula: C₂₂H₂₇ClF₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 428.90

Ref: 4Z-H-021001

Halobetasol

Controlled Product

CAS: 98651-66-2

Stability Hygroscopic
Applications Halobetasol is a corticosteroid, an anti-inflammatory drug that is used to treat various dermatological conditions which mainly consist of various forms of psoriasis.
References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011); Spuls, P. I. et al.: J. Dermatolog. Treat., 14, 21 (2003); Wong, J. et al.: J. Drugs, Dermatol., 11, 957 (2012);

Formula: C₂₂H₂₇ClF₂O₄

Color and Shape: Neat

Molecular weight: 428.90

Ref: TR-H102290

Halobetasol-d3

Controlled Product

CAS: 98651-66-2

Applications Halobetasol is a corticosteroid, an anti-inflammatory drug that is used to treat various dermatological conditions which mainly consist of various forms of psoriasis. This is the labelled isomer.
References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011); Spuls, P. I. et al.: J. Dermatolog. Treat., 14, 21 (2003); Wong, J. et al.: J. Drugs, Dermatol., 11, 957 (2012);

Formula: C₂₂D₃H₂₄ClF₂O₄

Color and Shape: Neat

Molecular weight: 431.916

Ref: TR-H102292

Halobetasol

Controlled Product

CAS: 98651-66-2

Halobetasol is a corticosteroid that is used to treat inflammatory skin diseases and bowel disease. It is available in the form of halobetasol propionate. Halobetasol propionate has been shown to be effective for psoriasis, atopic dermatitis, and other forms of inflammatory skin disease. In addition, it is also used to treat bowel disease such as ulcerative colitis and Crohn's disease. The side effects of this drug may include skin thinning, stretch marks, bruising, or an increase in blood pressure. This drug should not be taken by people with autoimmune diseases or infectious diseases. Halobetasol propionate can cause a decrease in the number of white blood cells (leukopenia), which makes it unsuitable for use in patients with conditions that require a high level of white cells (such as HIV).

Formula: C₂₂H₂₇ClF₂O₄

Purity: Min. 95%

Molecular weight: 428.9 g/mol

Ref: 3D-FH157973

Halobetasol

CAS: 98651-66-2

Halobetasol (Ulobetasol), a corticosteroid, is utilized in the research of severe localized psoriasis [1].

Formula: C₂₂H₂₇ClF₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 428.9

Ref: TM-T78512