CAS 987-02-0

Demecycline

Description:

Demecycline is a tetracycline antibiotic that is primarily used in the treatment of various bacterial infections. It is characterized by its broad-spectrum activity against both Gram-positive and Gram-negative bacteria, making it effective in treating conditions such as respiratory tract infections, urinary tract infections, and certain skin infections. Chemically, demecycline is known for its ability to inhibit protein synthesis in bacteria by binding to the 30S ribosomal subunit, thereby preventing the translation of mRNA. This compound is also notable for its use in the management of conditions like nephrogenic diabetes insipidus due to its ability to enhance the action of antidiuretic hormone. Demecycline is typically administered orally and is absorbed well in the gastrointestinal tract. However, it can cause side effects such as gastrointestinal disturbances and photosensitivity. As with other tetracyclines, it is contraindicated in children and pregnant women due to potential effects on bone and teeth development. Its chemical structure includes a naphthacene ring system, which is characteristic of tetracycline antibiotics.

Formula: C₂₁H₂₂N₂O₈

InChI: InChI=1/C21H22N2O8/c1-23(2)14-9-6-8-12(16(26)11-7(15(8)25)4-3-5-10(11)24)18(28)21(9,31)19(29)13(17(14)27)20(22)30/h3-5,8-9,14-15,24-26,30-31H,6,22H2,1-2H3/b20-13-/t8-,9-,14-,15+,21-/m0/s1

Synonyms:

• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-
• 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide
• 4beta-Dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6alpha,10,12,12abeta-pentahydro-1,11-dioxo-2-naphthacencarboxamid
• 6-Demethyltetracyclin
• Cl 22415
• Demeciclina
• Demecyclinum
• Demethyltetracycline
• Unii-Tv240Ch11P
• (2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione

Demeclocycline EP Impurity A (6-Demethyltetracycline)

CAS: 987-02-0

Formula: C₂₁H₂₂N₂O₈

Molecular weight: 430.41

Ref: 4Z-D-723

Demethyltetracycline (>90%)

Controlled Product

CAS: 987-02-0

Stability Light Sensitive
Applications Demethyltetracycline is a Chlortetracycline (C426500) metabolite, an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial.
References Hansen, HJ., et al.: P. Soc. Exp. Biol. Med., 113, 163 (1963); Skaletzki, B., et al.: Pharmazie, 29, 424 (1974); Martinez, M., et al.: Biochemistry, 40, 11965 (2001); Davidson, P., et al.: Food Technol., 55, 69 (2002); de la Fuente, R., et al.: Br. J. Pharmacol., 149, 551 (2006),

Formula: C₂₁H₂₂N₂O₈

Purity: >90%

Color and Shape: Beige To Brown

Molecular weight: 430.41

Ref: TR-D231115

Demecycline

CAS: 987-02-0

Demecycline is an antibiotic.

Formula: C₂₁H₂₂N₂O₈

Color and Shape: Solid

Molecular weight: 430.413

Ref: TM-T27144

Demethyltetracycline

CAS: 987-02-0

Demethyltetracycline is a tetracycline antibiotic that is structurally related to erythromycin. This drug inhibits the growth of bacteria by binding to the bacterial ribosome and blocking protein synthesis. Demethyltetracycline is used in the treatment of inflammatory diseases such as arthritis, but it is not effective against acid-fast bacteria. Demethyltetracycline binds to the sulfated glycosaminoglycan chondroitin which may serve as a carbon source for bacterial growth. The drug also has been shown to inhibit citric acid production in bacteria, which may be due to its ability to bind with chloride ions. Demethyltetracycline has been used in diagnostic agents such as a strain-specific mutant antibiotic and polyethylene glycols, which are added as solvents for this agent.

Formula: C₂₁H₂₂N₂O₈

Purity: 90%Min

Molecular weight: 430.41 g/mol

Ref: 3D-FD175015

Demeclocycline EP Impurity A

CAS: 987-02-0

Formula: C₂₁H₂₂N₂O₈

Molecular weight: 430.4

Ref: ST-EA-CP-D131001