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CAS 98717-16-9

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(+)-Ropivacaine

Description:
(+)-Ropivacaine is a local anesthetic belonging to the amide class, primarily used for regional anesthesia and pain management. It is characterized by its ability to block nerve conduction by inhibiting sodium ion influx through voltage-gated sodium channels, thereby preventing the initiation and propagation of nerve impulses. This compound is known for its long duration of action and lower cardiotoxicity compared to other local anesthetics, making it a preferred choice in various clinical settings. (+)-Ropivacaine is typically administered via injection and is often used in epidural and peripheral nerve blocks. Its chemical structure includes a piperidine ring, which contributes to its anesthetic properties. The substance is chiral, with the (+) enantiomer being the active form that exhibits greater potency and efficacy in clinical applications. Additionally, it is soluble in water and has a relatively low pKa, which influences its onset of action and duration. Overall, (+)-Ropivacaine is valued for its effectiveness in managing pain while minimizing potential side effects.
Formula:C17H26N2O
InChI:InChI=1S/C17H26N2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20)/t15-/m1/s1
InChI key:InChIKey=ZKMNUMMKYBVTFN-OAHLLOKOSA-N
SMILES:C(NC1=C(C)C=CC=C1C)(=O)[C@@H]2N(CCC)CCCC2
Synonyms:
  • (R)-Ropivacaine
  • 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (R)-
  • (2R)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide
  • (+)-Ropivacaine
  • 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2R)-
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