CAS 98719-20-1

Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl-

Description:

Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl- is a complex organic compound characterized by its unique structural features, including a benzofuroquinolizine core. This compound contains multiple functional groups, such as a sulfonamide and a hydroxyl group, which contribute to its chemical reactivity and potential biological activity. The presence of a chiral center in its structure indicates that it may exhibit stereoisomerism, which can influence its pharmacological properties. Ethanesulfonamide derivatives are often studied for their potential therapeutic applications, particularly in the fields of medicinal chemistry and drug development. The compound's solubility, stability, and interaction with biological targets are critical factors that determine its efficacy and safety profile. As with many sulfonamides, it may also exhibit antibacterial properties, although specific biological activities would require further investigation. Overall, this compound represents a fascinating area of study within organic and medicinal chemistry.

Formula: C₁₈H₂₄N₂O₄S

Synonyms:

• Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl-

L-654284

CAS: 98719-20-1

L-654284 is an α2-adrenergic receptor antagonist characterized by its notable selectivity. It competes with 3H-clonidine and 3H-rauwolscine for binding in vitro, exhibiting Ki values of 0.8 nM and 1.1 nM, respectively. L-654284 effectively blocks the pre-ejaculatory effects of clonidine in isolated rat vas deferens, with a pA2 value of 9.1. The compound demonstrates significant selectivity for α2 over α1 adrenergic receptors, with a Ki value of 110 nM against 3H-prazosin binding. In vivo, L-654284 significantly increases the turnover of norepinephrine in the rat cerebral cortex, indicating its activity in blocking α2-adrenergic receptors within the central nervous system.

Formula: C₁₈H₂₄N₂O₄S

Color and Shape: Solid

Molecular weight: 364.46

Ref: TM-T201031