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CAS 98796-51-1
:Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
Description:
Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], commonly referred to by its CAS number 98796-51-1, is a synthetic nucleoside derivative used primarily in the field of molecular biology and biochemistry. This compound features a thymidine base, which is a component of DNA, modified at both the 5' and 3' positions. The 5' position is substituted with a bis(4-methoxyphenyl)phenylmethyl group, enhancing its stability and solubility, while the 3' position is modified with a cyanoethyl phosphoramidite moiety, which is crucial for its role in oligonucleotide synthesis. The presence of the phosphoramidite group allows for the incorporation of this compound into DNA strands during solid-phase synthesis, making it valuable for producing custom oligonucleotides for research and therapeutic applications. Its structural characteristics contribute to its reactivity and utility in various biochemical processes, particularly in the synthesis of DNA and RNA analogs.
Formula:C40H49N4O8P
InChI:InChI=1/C10H14N2O5.C3H6N2O2P/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8;1-3(2-4)7-8(5)6/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16);3H,5H2,1H3/q;-1/t6-,7+,8+;/m0./s1
InChI key:InChIKey=UNOTXUFIWPRZJX-CEXSRUIHSA-N
SMILES:C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@@H](O1)N2C(=O)NC(=O)C(C)=C2)(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5
Synonyms:- 5'-Dimethoxytrityl-3'-deoxythymidine 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
- 5'-O-(4,4'-Dimethoxytrityl)-thymidine-3'-cyanoethyl Phosphoramidite
- 5′-O-(4,4′-Dimethoxytrityl)thymidine 3′-(2-cyanoethyl-N,N-diisopropylphosphoramidite)
- 5′-O-(4,4′-Dimethoxytriyl)thymidine 3′-(2-cyanoethyl)-N,N-diisopropylphosphoramidite
- 5′-O-DMT-thymidine 3′-CE phosphoramidite
- DMT-dT phosphoramidite
- DNA T Phosphoramidite
- DT-CE phosphoramidite
- Deoxythymidine phosphoramidite
- Thymidine phosphoramidite
- Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
- Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
- dT Phosphoramidite
- DMT-dT Amidite 1g, 60ml vial, 12 Pack
- DMT-dT amidite
- T-CE phosphoramidite
- 5'-DMT-dT phosphoramidite
- 5'-O-(4,4'-Dimethoxytrityl)thymidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite
- thymidine-ce phosphoramidite for*biosearch 8000
- 3'-O-P-5'-O-DMT-2'-DEOXY-THYRIDINE [DT PHOSPHORAMIDITE]
- 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-thymidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
- DMT-DT AMIDITE 1G AB 12 PACK
- 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-5-methyluridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite
- 5'-O-DMT-2'-deoxythymidine-3'-CE Phosphoramidite
- DMT-dT Amidite 2g, 60ml vial, 12 Pack
- 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYTHYMIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
- DMT-DT AMIDITE 2G 89 12 PACK
- REF DUPL: dT Phosphoramidite
- 5'-O-[Bis(4-Methoxyphenyl)phenylMethyl]-thyMidine 3'-[2-cyanoethyl N,N-bis(1-Methylethyl)phosphoraMidite]
- 5'-O-Dimethoxytrityl-2'-deoxy-thymidine-3'-O-(2-cyanoethyl)-Phosphoramidite
- N-blocked-5'-O-DMT 3'-CED thymidine phosphoramidite
- DMT-dT-CE-Phosphoramidite
- DMT-DT AMIDITE 10G SINGLE
- (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
- 5'-O-DMT-N2-isobutyryl-2'-de5'-O-DMT-Thymidine 3'-CE phosphoramidite
- DMT-dT Amidite 6.85g, 6 Pack
- 5'-O-DMT- 2'-Deoxy Thymidine Phosphoramidite
- DMT-DT AMIDITE 5G SINGLE
- DMT-DT AMIDITE 4G 60ML VIAL 12 PACK
- 5′-O-(4,4′-dimethoxytrityl)-2′-deoxythymidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
- DMT-DT AMIDITE 2G AB 12 PACK
- DMT-dT Pharmadite
- Thymidine-3'-phosphoramidite
- DMT-DT AMIDITE 5G 6 PACK
- DMT-THYMIDINE CED PHOSPHORAMIDITE
- 5''-O-(4,4''-Dimethoxytrityl)-thymidine-3''-N,N-diisopropyl-(2-cyanoethyl)-pho
- DNAT-PHOSPHORAMIDITE
- 5'-O-(DIMETHOXYTRITYL)-THYMIDINE-3'-N,N-DIISOPROPYL(CYANOETHYL)PHOSPHORAMIDITE
- DMT-DT AMIDITE 20G 6 PACK
- See more synonyms
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Found 9 products.
DMT-dT Phosphoramidite
CAS:Formula:C40H49N4O8PPurity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:744.83T β-Cyanoethyl Phosphoramidite (5'-O-Dimethoxytritylthymidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite)
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C40H49N4O8PColor and Shape:White PowderMolecular weight:744.3288Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite]
CAS:Formula:C40H49N4O8PPurity:97%Color and Shape:SolidMolecular weight:744.8128DMT-dT Phosphoramidite
CAS:<p>DMT-dT Phosphoramidite is typically used in the synthesis of DNA.</p>Formula:C40H49N4O8PColor and Shape:SolidMolecular weight:744.815'-O-DMT-thymidine 3'-CE phosphoramidite
CAS:<p>5'-O-DMT-thymidine 3'-CE phosphoramidite is a building block for the introduction of thymidine units into oligonucleotides. 5'-O-DMT-thymidine 3'-CE phosphoramidite is utilised in a broad range of applications, including the synthesis of natural and unnatural DNA and RNA strands. Phosphoramidites are the reagent class of choice for oligonucleotide synthesis as they contain readily removable orthogonal protecting groups and can be produced at reasonable scales. The diisopropylamino leaving group is readily cleaved upon exposure to an azole catalyst allowing for a highly efficient coupling reaction with a free hydroxyl group on the growing oligonucleotide and oxidation of the subsequent phosphite triester, followed by beta-elimination of the cyanoethyl group affords the stable phosphodiester linkage.</p>Formula:C40H49N4O8PPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:744.83 g/mol
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