CAS 989-96-8

(11β,16α)-9-Fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-21-(phosphonooxy)pregna-1,4-diene-3,20-dione

Description:

The chemical substance known as "(11β,16α)-9-Fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-21-(phosphonooxy)pregna-1,4-diene-3,20-dione," with the CAS number 989-96-8, is a synthetic corticosteroid. It exhibits anti-inflammatory and immunosuppressive properties, making it useful in various therapeutic applications, particularly in the treatment of conditions such as asthma, allergies, and autoimmune disorders. The structure of this compound features a fluorine atom, hydroxyl groups, and a phosphonooxy moiety, which contribute to its biological activity and pharmacokinetics. The presence of the steroid backbone allows it to interact with glucocorticoid receptors, influencing gene expression and modulating inflammatory responses. Additionally, the compound's stability and solubility characteristics are essential for its formulation in pharmaceutical preparations. As with many corticosteroids, careful consideration of dosage and potential side effects is necessary to optimize therapeutic outcomes while minimizing adverse reactions.

Formula: C₂₄H₃₂FO₉P

InChI: InChI=1/C24H32FO9P/c1-20(2)33-19-10-16-15-6-5-13-9-14(26)7-8-21(13,3)23(15,25)17(27)11-22(16,4)24(19,34-20)18(28)12-32-35(29,30)31/h7-9,15-17,19,27H,5-6,10-12H2,1-4H3,(H2,29,30,31)/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1

InChI key: InChIKey=NXLTXRVPGUCAHF-JNQJZLCISA-N

SMILES: C(COP(=O)(O)O)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)(C)O2)[H])([C@]4([C@](F)([C@@H](O)C3)[C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H]

Synonyms:

• (11β,16α)-9-Fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-21-(phosphonooxy)pregna-1,4-diene-3,20-dione
• 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl dihydrogen phosphate
• 2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregna-1,4-diene-3,20-dione deriv.
• 9-Fluoro-11beta,21-dihydroxy-16alpha,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate)
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-21-(phosphonooxy)-, (11β,16α)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-(dihydrogen phosphate)
• Triamcinolone acetonide 21-(dihydrogen phosphate)
• Triamcinolone acetonide 21-phosphate