CAS 99102-04-2

Erythrohydrobupropion

Description:

Erythrohydrobupropion is a chemical compound that serves as a metabolite of bupropion, an antidepressant and smoking cessation aid. It is characterized by its structural features, which include a piperidine ring and a ketone functional group, contributing to its pharmacological properties. The compound is known for its potential role in modulating neurotransmitter activity, particularly dopamine and norepinephrine, which may influence mood and behavior. Erythrohydrobupropion is typically studied in the context of its effects on the central nervous system and its implications in treating conditions such as depression and anxiety. Its solubility and stability in various solvents can vary, impacting its bioavailability and therapeutic efficacy. As a metabolite, it is important in understanding the pharmacokinetics of bupropion, including how the body processes and eliminates the drug. Research continues to explore its specific effects and potential therapeutic applications, as well as its safety profile in comparison to its parent compound.

Formula: C₁₃H₂₀ClNO

InChI: InChI=1/C13H20ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,12,15-16H,1-4H3/t9-,12-/s2

InChI key: InChIKey=NDPTTXIBLSWNSF-RKRUEEIYNA-N

SMILES: [C@H]([C@H](NC(C)(C)C)C)(O)C1=CC(Cl)=CC=C1

Synonyms:

• (1S,2R)-2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-ol
• Benzenemethanol, 3-chloro-α-[(1R)-1-[(1,1-dimethylethyl)amino]ethyl]-, (αS)-rel-
• Benzenemethanol, 3-chloro-α-[1-[(1,1-dimethylethyl)amino]ethyl]-, (R*,S*)-
• Erythrohydrobupropion
• Erythrohydroxybupropion
• rel-(αS)-3-Chloro-α-[(1R)-1-[(1,1-dimethylethyl)amino]ethyl]benzenemethanol

erythro-Dihydro Bupropion-d9 Hydrochloride

Controlled Product

CAS: 80478-43-9, 99102-04-2

Applications erythro-Dihydro Bupropion-d9 Hydrochloride is the labeled hydrochloride salt analogue of erythro-Dihydro Bupropion (D448650), a metabolite of the drug Bupropion (B689625), a selective inhibitor of dopamine uptake. An antidepressant of the aminoketone class; aid in smoking cessation.
References Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997); Soroko, F., et al.: J. Pharm. Pharmacol., 29, 769 (1977); Tucker, W.E., J. Clin. Psychiatry, 44, 60 (1983); Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997); West, R., et al.: Expert Opin. Pharmacother., 4, 533 (2003)

Formula: C₁₃H₁₂D₉Cl₂NO

Color and Shape: Neat

Molecular weight: 287.27

Ref: TR-D448653

rac erythro-Dihydro Bupropion

Controlled Product

CAS: 99102-04-2

Formula: C₁₃H₂₀ClNO

Color and Shape: White To Light Yellow

Molecular weight: 241.76

Ref: TR-D448650

rel-(1R,2S)-erythro-Dihydro Bupropion Maleate

CAS: 99102-04-2

Applications (1R,2S)-erythro-Dihydro Bupropion Maleate is a metabolite of Bupropion (B689625), a selective inhibitor of dopamine uptake. An antidepressant of the aminoketone class; aid in smoking cessation.
References Writer, J.H., et. al.: Sci. Total Environ., 461 (2013)

Formula: C₁₃H₂₀ClNO·C₄H₄O₄

Color and Shape: White

Molecular weight: 357.829

Ref: TR-D448660

rac erythro-dihydro bupropion

Controlled Product

CAS: 99102-04-2

RAC is a prodrug of the active form, bupropion. The drug is metabolized in the liver to its active form and has a half-life of about 12 hours. It is distributed throughout the body, including maternal blood, and can be measured by an analytical method. RAC has been shown to have no effect on 5-HT2A receptors, but it inhibits other receptors that are involved in the regulation of mood, appetite, sleep, and cognition by binding to them as a substrate molecule. RAC has been used for the treatment of attention-deficit/hyperactivity disorder (ADHD) in humans; it also improves performance on rotarod tests in rats and is being studied as a potential treatment for Alzheimer's disease.

Formula: C₁₃H₂₀ClNO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 241.76 g/mol

Ref: 3D-FR27514