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CAS 99200-09-6

:

Nebivolol

Description:
Nebivolol is a selective beta-1 adrenergic receptor blocker primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to lower blood pressure by reducing heart rate and myocardial contractility, leading to decreased cardiac output. Nebivolol is unique among beta-blockers due to its vasodilatory properties, which are attributed to its ability to stimulate the release of nitric oxide, promoting vascular relaxation. The substance is typically administered orally and has a favorable pharmacokinetic profile, including a long half-life that allows for once-daily dosing. Nebivolol is generally well-tolerated, with a side effect profile that may include fatigue, headache, and gastrointestinal disturbances. Its selectivity for beta-1 receptors makes it a preferred choice in patients with respiratory conditions, as it minimizes the risk of bronchoconstriction associated with non-selective beta-blockers. Overall, Nebivolol represents a significant advancement in cardiovascular pharmacotherapy, combining efficacy with a relatively low incidence of adverse effects.
Formula:C22H25F2NO4
InChI:InChI=1/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2
InChI key:InChIKey=KOHIRBRYDXPAMZ-UHFFFAOYSA-N
SMILES:C(CNCC(O)C1OC=2C(CC1)=CC(F)=CC2)(O)C3OC=4C(CC3)=CC(F)=CC4
Synonyms:
  • (iminobis(methylene))bis(6-fluoro-3,4-dihydro-
  • 1-(6-Fluoro-chroman-2-yl)-2-[2-(6-fluoro-chroman-2-yl)-2-hydroxy-ethylamino]-ethanol
  • 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]
  • 2H-1-Benzopyran-2-methanol, alpha,alpha'-
  • 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-
  • 2H-1-benzopyran-2-methanol)
  • Nebivolol-D4
  • Nibivolol
  • [2R*[R*[R*(S*)]]]-alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol
  • alpha,alpha'-(Iminobis(methylene))bis(6-fluoro-3,4-dihydro-
  • See more synonyms
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Found 5 products.