CAS 99248-33-6

cyclo(N-methyl-L-alanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl) acetate

Description:

Cyclo(N-methyl-L-alanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl) acetate, with the CAS number 99248-33-6, is a cyclic peptide that features a unique sequence of amino acids, including both L- and D-forms, which contributes to its structural and functional properties. This compound is characterized by its cyclic structure, which can enhance stability and bioactivity compared to linear peptides. The presence of N-methylation in the alanine residue may influence its binding affinity and resistance to enzymatic degradation. The incorporation of aromatic amino acids like tyrosine, tryptophan, and phenylalanine can impart specific interactions with biological targets, potentially affecting its pharmacological profile. Additionally, the acetate group may play a role in solubility and overall molecular interactions. Such cyclic peptides are of interest in medicinal chemistry for their potential applications in drug design, particularly in targeting specific receptors or enzymes due to their conformational rigidity and ability to mimic natural peptides.

Formula: C₄₆H₆₀N₈O₉

InChI: InChI=1/C44H56N8O7.C2H4O2/c1-26(2)38-43(58)50-37(23-28-12-6-5-7-13-28)44(59)52(4)27(3)39(54)48-35(22-29-17-19-31(53)20-18-29)41(56)49-36(24-30-25-46-33-15-9-8-14-32(30)33)42(57)47-34(40(55)51-38)16-10-11-21-45;1-2(3)4/h5-9,12-15,17-20,25-27,34-38,46,53H,10-11,16,21-24,45H2,1-4H3,(H,47,57)(H,48,54)(H,49,56)(H,50,58)(H,51,55);1H3,(H,3,4)/t27-,34-,35-,36+,37-,38-;/m0./s1

Synonyms:

• Cyclo(N-methyl-L-alanyl-4-amino-L-phenylalanyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl) Monoacetate (Salt)
• cyclo-(N-Me-Ala-Tyr-D-Trp-Lys-Val-Phe)
• Cyclo(N-methyl-L-alanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl)-monoacetate (salt).
• Seglitide acetate

Seglitide acetate

CAS: 99248-33-6

Seglitide acetate

Purity: ≥98%

Molecular weight: 869.02g/mol

Ref: 54-BUP03171

Seglitide acetate

CAS: 99248-33-6

Seglitide acetate (MK-678) is a selective agonist of sst2 somatostatin receptor.

Formula: C₄₆H₆₀N₈O₉

Purity: 98.87%

Color and Shape: Solid

Molecular weight: 869.02

Ref: TM-T28743

Seglitide acetate

Controlled Product

CAS: 99248-33-6

Seglitide is a cyclic peptide that is a model system for the receptor activity of somatostatin. Somatostatin inhibits cells by binding to its receptors, which are found on the surface of endocrine cells and in the hypothalamus. Seglitide has been shown to inhibit cell growth in tissue culture and is a potent inhibitor of epidermal growth factor (EGF) production. Seglitide also activates locomotor activity in mice, suggesting that it may have some clinical relevance. Structural analysis has revealed that seglitide's amino acid sequence is similar to somatostatin's, making them closely related compounds. It also binds to DNA-dependent RNA polymerase, preventing transcription and replication.

Formula: C₄₄H₅₆N₈O₇·C₂H₄O₂

Purity: Min. 95%

Molecular weight: 869.02 g/mol

Ref: 3D-GDA37702