CAS 99295-33-7

8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol

Description:

8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol is a chemical compound characterized by its complex bicyclic structure, which includes a benzazepine framework. This compound features a bromine atom at the 8-position and a hydroxyl group at the 7-position, contributing to its reactivity and potential biological activity. The presence of a phenyl group and a methyl group enhances its lipophilicity, which may influence its pharmacokinetic properties. The tetrahydro configuration indicates that the compound is partially saturated, which can affect its conformational flexibility and interactions with biological targets. As a member of the benzazepine class, it may exhibit various pharmacological effects, including potential neuroactive properties. The compound's CAS number, 99295-33-7, allows for its identification in chemical databases, facilitating research and development in medicinal chemistry. Overall, this compound's unique structural features suggest potential applications in drug discovery and development, particularly in the fields of psychiatry and neurology.

Formula: C₁₇H₁₈BrNO

InChI: InChI=1S/C17H18BrNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3

InChI key: InChIKey=XFTVOHWWEQGXLS-UHFFFAOYSA-N

SMILES: OC=1C=C2C(CN(C)CCC2=CC1Br)C3=CC=CC=C3

Synonyms:

• 1H-3-Benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, (±)-
• SKF 83566
• 1H-3-Benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-
• 8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol

SKF-83566

CAS: 99295-33-7

SKF-83566

Purity: ≥98%

Molecular weight: 332.23g/mol

Ref: 54-BUP20849

SKF-83566

CAS: 99295-33-7

SKF-83566: Blood-brain permeable, orally active D1 dopamine antagonist; weaker 5-HT2 antagonist, Ki=11 nM.

Formula: C₁₇H₁₈BrNO

Purity: 95.00% - 99.82%

Color and Shape: Solid

Molecular weight: 332.23

Ref: TM-T8702

SKF-83566

CAS: 99295-33-7

SKF-83566 is a synthetic compound that acts as a selective dopamine receptor D1 antagonist, derived from organic chemical synthesis. This compound effectively binds to dopamine D1 receptors, thereby inhibiting the physiological actions mediated by these receptors in the central nervous system (CNS). SKF-83566 is instrumental in research focusing on the dopaminergic system, allowing scientists to dissect the complex role of dopamine in neurobiological processes. Its ability to selectively block D1 receptors makes it an invaluable tool in the study of neurological disorders such as schizophrenia, Parkinson's disease, and addiction, where dopamine signaling plays a crucial role. Researchers employ SKF-83566 to investigate signal transduction pathways, receptor pharmacology, and the behavioral outcomes of altered dopaminergic activity. By modulating receptor activity, SKF-83566 contributes to our understanding of neurophysiological mechanisms and furthers the development of potential therapeutic approaches. Its precise interaction with D1 receptors provides clarity in experimental outcomes, shedding light on the nuanced dynamics of brain function and dysfunction.

Formula: C₁₇H₁₈BrNO

Purity: Min. 95%

Molecular weight: 332.2 g/mol

Ref: 3D-ZDA29533