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CAS 99306-64-6

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Boc-Arg-pNA・HCl

Description:
Boc-Arg-pNA·HCl, also known as Nα-Boc-L-arginine p-nitroanilide hydrochloride, is a chemical compound commonly used in biochemical research, particularly in the study of proteases and enzyme activity. It features a Boc (tert-butyloxycarbonyl) protecting group on the arginine side chain, which enhances its stability and solubility. The p-nitroanilide moiety serves as a chromogenic substrate, allowing for the detection of enzymatic activity through colorimetric changes. This compound is typically a white to off-white solid and is soluble in polar solvents such as water and methanol. The hydrochloride salt form aids in its stability and handling. In terms of reactivity, Boc-Arg-pNA·HCl can be hydrolyzed under acidic or basic conditions, releasing the active arginine and the p-nitroaniline, which can be monitored spectrophotometrically. Its applications extend to peptide synthesis and as a substrate in assays for various enzymes, making it a valuable tool in biochemical and pharmaceutical research.
Formula:C17H27ClN6O5
InChI:InChI=1/C17H26N6O5.ClH/c1-17(2,3)28-16(25)22-13(5-4-10-20-15(18)19)14(24)21-11-6-8-12(9-7-11)23(26)27;/h6-9,13H,4-5,10H2,1-3H3,(H,21,24)(H,22,25)(H4,18,19,20);1H/t13-;/m0./s1
Synonyms:
  • N^(alpha)-(tert-Butoxycarbonyl)-L-arginine 4-Nitroanilide hydrochloride
  • N2-(tert-butoxycarbonyl)-N-(4-nitrophenyl)-L-argininamide hydrochloride
  • Butoxycarbonylargininenitroanilide hydrochlorid
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