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CAS 99495-92-8

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(S)-Flecainide

Description:
(S)-Flecainide is a pharmaceutical compound primarily used as an antiarrhythmic agent to treat certain types of irregular heartbeats, particularly atrial fibrillation and ventricular tachycardia. It belongs to the class of sodium channel blockers, which work by inhibiting the influx of sodium ions during the cardiac action potential, thereby stabilizing the cardiac membrane and reducing excitability. The substance is characterized by its chiral nature, with the (S)-enantiomer being the therapeutically active form. Its molecular structure includes a phenyl ring and a piperidine moiety, contributing to its pharmacological properties. (S)-Flecainide is typically administered orally and is known for its relatively long half-life, allowing for less frequent dosing. However, it can have significant side effects, including proarrhythmia, particularly in patients with structural heart disease. Monitoring is essential during treatment to ensure efficacy and safety. As with any medication, it is crucial to use (S)-Flecainide under the guidance of a healthcare professional.
Formula:C17H20F6N2O3
InChI:InChI=1/C17H20F6N2O3/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26)/t11-/m0/s1
InChI key:InChIKey=DJBNUMBKLMJRSA-NSHDSACASA-N
SMILES:C(NC[C@@H]1CCCCN1)(=O)C2=C(OCC(F)(F)F)C=CC(OCC(F)(F)F)=C2
Synonyms:
  • (+)-Flecainide
  • (S)-(+)-Flecainide
  • Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, (S)-
  • N-[(2S)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • benzamide, N-[(2S)-2-piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)-
  • N-[(S)-2-Piperidylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • N-[[(2S)-piperidin-2-yl]methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • Flecainide Impurity 7
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