CAS 99522-79-9

Pranidipine

Description:

Pranidipine is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation, reducing peripheral vascular resistance and lowering blood pressure. Pranidipine is characterized by its selective action on vascular smooth muscle, which minimizes cardiac side effects compared to other calcium channel blockers. The compound has a relatively long half-life, allowing for once-daily dosing, which can enhance patient compliance. Its pharmacokinetics include good oral bioavailability and extensive hepatic metabolism. Pranidipine is generally well-tolerated, but like other medications in its class, it may cause side effects such as headache, flushing, and peripheral edema. As with any medication, it is important for patients to consult healthcare professionals for personalized advice and to discuss potential interactions with other drugs.

Formula: C₂₅H₂₄N₂O₆

InChI: InChI=1/C25H24N2O6/c1-16-21(24(28)32-3)23(19-12-7-13-20(15-19)27(30)31)22(17(2)26-16)25(29)33-14-8-11-18-9-5-4-6-10-18/h4-13,15,23,26H,14H2,1-3H3/b11-8+

InChI key: InChIKey=XTFPDGZNWTZCMF-DHZHZOJONA-N

SMILES: C(OC/C=C/C1=CC=CC=C1)(=O)C=2C(C(C(OC)=O)=C(C)NC2C)C3=CC(N(=O)=O)=CC=C3

Synonyms:

• (E)-Cinnamyl methyl (+-)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(2E)-3-phenyl-2-propen-1-yl] ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (2E)-3-phenyl-2-propenyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 3-phenyl-2-propenyl ester, (E)-
• Acalas
• Brn 5654325
• Ccris 6666
• Frc 8411
• Methyl cinnamyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate
• Opc 13340
• Pranidipine [INN]
• Unii-9Des9Qvh58
• methyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• trans-Cinnamyl methyl 4-(3-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[(E)-3-phenyl-2-propenyl] ester
• 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl (2E)-3-phenyl-2-propenyl ester
• Pranidipine
• 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(E)-3-phenyl-2-propenyl] ester

Pranidipine

CAS: 99522-79-9

Pranidipine

Purity: ≥98%

Molecular weight: 448.47g/mol

Ref: 54-BUP05088

Pranidipine

CAS: 99522-79-9

Pranidipine (OPC-13340) is a novel, long-acting 1,4-dihydropyridine calcium channel blocker.

Formula: C₂₅H₂₄N₂O₆

Purity: 99.95%

Color and Shape: Yellow Solid

Molecular weight: 448.47

Ref: TM-T16571

Pranidipine

CAS: 99522-79-9

Applications A novel calcium channel antagonist; cardiovascular agent.
References Matsumori, A., et al.: Circulation, 66, 355 (1982), Roberts, W., et al.: Am. J. Cardiol., 60, 1340 (1987), Uehara, Y., et al.: J. Cardiovasc. Pharmacol., 23, 970 (1994), Kim, C., et al.: Cardiovasc. Drugs Ther., 13, 455 (1999), Watanabe, K., et al.: Br. J. Pharmacol., 130, 1489 (2000),

Formula: C₂₅H₂₄N₂O₆

Color and Shape: Neat

Molecular weight: 448.47

Ref: TR-P700950