CAS 99533-80-9

(+)-K 252a

Description:

(+)-K 252a is a natural product derived from the fermentation of the bacterium Streptomyces, known for its potent biological activities. It is classified as a protein kinase inhibitor, specifically targeting various kinases involved in cellular signaling pathways. This compound exhibits a complex structure characterized by a tetracyclic core, which contributes to its ability to modulate cellular processes such as growth, differentiation, and apoptosis. (+)-K 252a has shown promise in various pharmacological applications, including neuroprotective effects and potential anti-cancer properties. Its mechanism of action involves the inhibition of specific kinases, which can lead to alterations in cellular signaling cascades. Additionally, it has been studied for its effects on neurotransmitter release and neuronal survival. Due to its biological significance, (+)-K 252a serves as a valuable tool in biochemical research and has potential therapeutic implications, although further studies are necessary to fully understand its efficacy and safety in clinical settings.

Formula: C₂₇H₂₁N₃O₅

InChI: InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1

InChI key: InChIKey=KOZFSFOOLUUIGY-SOLYNIJKSA-N

SMILES: C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@]2(C(OC)=O)O)[H])=CC=CC8

Synonyms:

• (+)-K 252a
• 9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)-
• 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-
• 9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R)-
• 9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, [9S-(9α,10β,12α)]-
• Antibiotic K 252a
• Antibiotic SF 2370
• K 252
• K 252a Nocardiopsis sp.
• K252a
• Protein kinase inhibitor K252a
• Sf 2370
• methyl (5S,6R,8R)-6-hydroxy-5-methyl-13-oxo-5,6,7,8,14,15-hexahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacene-6-carboxylate

K-252a

CAS: 99533-80-9

Formula: C₂₇H₂₁N₃O₅

Purity: 100.0%

Color and Shape: Yellowish amorphous solid

Molecular weight: 467.0

Ref: 8R-JU0109

9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R)

CAS: 99533-80-9

Formula: C₂₇H₂₁N₃O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 467.4727

Ref: IN-DA00655S

K252a

CAS: 99533-80-9

K252a

Formula: C₂₇H₂₁N₃O₅

Purity: By hplc: 99.23% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 467.47g/mol

Ref: 54-BIK1001

K-252a

CAS: 99533-80-9

K-252a, staurosporine analog, inhibits various kinases (PKC 470nM, PKA 140nM, CaMKII 270nM, PhK 1.7nM), from Nocardiopsis sp. soil fungi.

Formula: C₂₇H₂₁N₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 467.47

Ref: TM-T15636

K-252a

CAS: 99533-80-9

Formula: C₂₇H₂₁N₃O₅

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 467.47

Ref: 7W-GL3770

K-252A

CAS: 99533-80-9

K-252A is an antimicrobial agent that inhibits the growth of bacteria. It binds to the response element in the promoter region of genes and blocks gene transcription, thereby preventing protein synthesis. K-252A has been shown to inhibit the growth of bacteria that are resistant to many other antibiotics, including ampicillin, chloramphenicol, clindamycin, erythromycin, gentamicin and kanamycin. This drug also induces significant up-regulation of cyclic nucleotide phosphodiesterases (PDE) and cytosolic Ca2+ in vitro. K-252A has been shown to cause neuronal death in vitro by inhibiting axonal growth. K-252A also inhibits leukemia inhibitory factor (LIF) from binding to its receptor on mouse lymphocytes.

Formula: C₂₇H₂₁N₃O₅

Purity: Min. 95%

Molecular weight: 467.49 g/mol

Ref: 3D-INK-3026-PI

K252a

Controlled Product

CAS: 99533-80-9

Applications K252a is a protein kinase inhibitor. It is an analogue of staurosporine (S685000). It shows potent antitumor activity but no antimicrobial activity in vitro, or in vivo toxicity in rodents.
References Kase, H., et al.: J. Antibiot., 39, 1059 (1986); Yasuzawa, T., et al.; J. Antibiot., 39, 1072 (1986)

Formula: C₂₇H₂₁N₃O₅

Color and Shape: Neat

Molecular weight: 467.47

Ref: TR-K000500

K252a

CAS: 99533-80-9

Inhibitor of TRK family of kinases

Formula: C₂₇H₂₁N₃O₅

Purity: Min. 95%

Molecular weight: 467.47 g/mol

Ref: 3D-FK45548

K252a

CAS: 99533-80-9

Formula: C₂₇H₂₁N₃O₅

Molecular weight: 467.48

Ref: 4Z-K-021001