CAS 99755-59-6

Rotigotine

Description:

Rotigotine is a synthetic dopamine agonist primarily used in the treatment of Parkinson's disease and restless legs syndrome. It acts by stimulating dopamine receptors in the brain, thereby helping to alleviate symptoms associated with dopamine deficiency. The substance is characterized by its lipophilic nature, which allows for transdermal delivery via a patch formulation, providing a steady release of the medication over time. Rotigotine has a relatively short half-life, necessitating continuous administration to maintain therapeutic levels. Its chemical structure includes a chiral center, which contributes to its pharmacological activity. Common side effects may include nausea, dizziness, and somnolence, reflecting its central nervous system activity. Rotigotine is classified under the category of non-ergoline dopamine agonists, distinguishing it from other treatments in the same class. As with any medication, careful monitoring is essential to manage potential adverse effects and ensure optimal therapeutic outcomes.

Formula: C₁₉H₂₅NOS

InChI: InChI=1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3/t16-/m0/s1

InChI key: InChIKey=KFQYTPMOWPVWEJ-INIZCTEOSA-N

SMILES: OC1=C2C(C[C@@H](N(CCC3=CC=CS3)CCC)CC2)=CC=C1

Synonyms:

• (-)-(S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol
• (-)-N 0437
• (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol
• (6S)-6-[Propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
• (6S)-6-{propyl[2-(thiophen-2-yl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol
• (S)-(-)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol
• (S)-(-)-Rotigotine
• (S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-naphth-1-ol
• (S)-6-[Propyl[2-(thiophen-2-yl)ethyl]amino]-5,6,7,8-tetrahydronaphthalen-1-ol
• 1-Naphthalenol 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (6S)-
• 1-Naphthalenol, 5,6,7,8-tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-
• 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (S)-
• 2-(N-n-Propyl-N-2-thienylethylamino)-5-hydroxytetralin
• 5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol
• 6-(Propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenol
• 6-{Propyl[2-(Thiophen-2-Yl)Ethyl]Amino}-5,6,7,8-Tetrahydronaphthalen-1-Ol
• Leganto
• N 0923
• Neupro

Rotigotine impurity standard

CAS: 99755-59-6

Rotigotine impurity standard

Color and Shape: White

Ref: 47-1243

Rotigotine

CAS: 99755-59-6

Rotigotine

Formula: C₁₉H₂₅NOS

Purity: 99.6%

Color and Shape: White

Molecular weight: 315.16569

Ref: 47-1242

ROTIGOTINE CRS

CAS: 99755-59-6

ROTIGOTINE CRS

Ref: 41-Y0002010

Rotigotine ((S)-6-{Propyl[2-(thiophen-2-yl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol)

CAS: 99755-59-6

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₉H₂₅NOS

Color and Shape: White Beige Powder

Molecular weight: 315.16569

Ref: 45-1606060

(6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol

CAS: 99755-59-6

Formula: C₁₉H₂₅NOS

Purity: 99%

Color and Shape: Solid

Molecular weight: 315.4729

Ref: IN-DA0039YJ

Rotigotine-

CAS: 99755-59-6

Rotigotine-

Purity: ≥98%

Molecular weight: 315.47g/mol

Ref: 54-BUP15521

Rotigotine

CAS: 99755-59-6

Rotigotine

Purity: 99%

Molecular weight: 315.47g/mol

Ref: 54-OR1023747

Rotigotine

CAS: 99755-59-6

Formula: C₁₉H₂₅NOS

Color and Shape: Neat

Molecular weight: 315.47

Ref: 86-MM1403.00

Rotigotine-

CAS: 99755-59-6

Rotigotine (N-0923) is a non-ergot dopamine receptor agonist used in the therapy of Parkinson disease and restless leg syndrome.

Formula: C₁₉H₂₅NOS

Purity: 98.08% - 99.59%

Color and Shape: Solid

Molecular weight: 315.47

Ref: TM-T6647

(6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol

Controlled Product

CAS: 99755-59-6

(6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol is a potent and selective dopamine receptor agonist. It acts by binding to the dopamine receptors in the brain. This binding stimulates the release of dopamine and prevents it from being reabsorbed into the neurons, which in turn increases levels of extracellular dopamine in the synapse. (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol has been shown to have antidepressant effects in animal models of depression. It also has a long half life and can be administered as a transdermal patch for prolonged relief from depression symptoms.

Formula: C₁₉H₂₅NOS

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 315.47 g/mol

Ref: 3D-FT76640

Rotigotine

CAS: 99755-59-6

Formula: C₁₉H₂₅NOS

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 315.48

Ref: 3B-R0220

Rotigotine

CAS: 99755-59-6

Formula: C₁₉H₂₅NOS

Purity: 99%

Molecular weight: 315.166

Ref: 10-F513052

Rotigotine

CAS: 99755-59-6

Color and Shape: Neat

Ref: 61-FOR1403.00