CAS 99768-12-4

4-(Methoxycarbonyl)phenylboronic acid

Description:

4-(Methoxycarbonyl)phenylboronic acid is an organic compound characterized by the presence of a boronic acid functional group attached to a phenyl ring that also carries a methoxycarbonyl substituent. This compound typically appears as a white to off-white solid and is soluble in polar organic solvents. The boronic acid group is known for its ability to form reversible covalent bonds with diols, making it useful in various applications, including organic synthesis and medicinal chemistry. The methoxycarbonyl group, which is an ester functional group, enhances the compound's reactivity and solubility properties. This compound can participate in Suzuki coupling reactions, a widely used method for forming carbon-carbon bonds in the synthesis of complex organic molecules. Additionally, due to its boronic acid functionality, it may exhibit potential in drug development, particularly in targeting specific biological pathways. Overall, 4-(Methoxycarbonyl)phenylboronic acid is a versatile building block in organic synthesis with applications in both research and industry.

Formula: C₈H₉BO₄

InChI: InChI=1/C8H9BO4/c1-13-8(10)6-2-4-7(5-3-6)9(11)12/h2-5,11-12H,1H3

InChI key: InChIKey=PQCXFUXRTRESBD-UHFFFAOYSA-N

SMILES: C(OC)(=O)C1=CC=C(B(O)O)C=C1

Synonyms:

• (4-Carbomethoxyphenyl)boronic acid
• 4-(Carbomethoxy)-phenylboronic acid
• 4-(Methoxycarbonyl)Benzeneboronic Acid
• 4-(Methoxycarbonyl)phenylboronic acid
• 4-Borono-benzoic acid 1-methyl ester
• 4-Carbomethoxybenzeneboronic acid
• 4-Dihydroxyborylbenzoic acid methyl ester
• 4-Methoxycarbonylbenzeneboronic acid
• 4-Methoxycarbonylphenylboric acid
• Benzoic acid, 4-borono-, 1-methyl ester
• Benzoic acid, p-borono-, methyl ester
• Methyl 4-boronobenzoate
• Methyl 4-carboxyphenylboronic acid
• Methyl p-boronobenzoate
• P-(Methoxycarbonyl)Phenylboronic Acid
• p-(Methoxycarbonyl)boronic acid
• 4-(Methoxycabonyl)phenylboronic acid
• 4-METHOXYCARBONYLPHENYLBORONIC ACID
• 4-CARBOMETHOXYPHENYLBORONIC ACID
• RARECHEM AH PB 0115
• 4-(Methoxycarbonyl)phenylboronic Acid (contains varying amounts of Anhydride)
• 4-METHOXYCATBONYLPHENYLBORONICACID
• 4-METHOXYCARBONYLPHENYLBORONIC ACID 97%

4-(Methoxycarbonyl)benzeneboronic acid, 97%

CAS: 99768-12-4

It is a reagent used for tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation sequence, copper-mediated ligandless aerobic fluoroalkylation of arylboronic acids with fluoroalkyl iodides, one-pot ipso-nitration of arylboronic acids, copper-catalyzed nitration and cycl

Formula: C₈H₉BO₄

Purity: 97%

Color and Shape: Powder, White

Molecular weight: 179.97

Ref: 02-H27627

Methyl 4-Boronobenzoate

CAS: 99768-12-4

Formula: C₈H₉BO₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 179.9657

Ref: IN-DA00357D

4-(Methoxycarbonyl)benzeneboronic acid

CAS: 99768-12-4

4-(Methoxycarbonyl)benzeneboronic acid

Formula: C₈H₉BO₄

Purity: 98%

Color and Shape: white powder

Molecular weight: 179.97g/mol

Ref: 54-OR5354

4-(Methoxycarbonyl)phenylboronic acid

CAS: 99768-12-4

Purity: 97%

Molecular weight: 179.97

Ref: FT-M3563

4-(Methoxycarbonyl)phenylboronic Acid (contains varying amounts of Anhydride)

CAS: 99768-12-4

Formula: C₈H₉BO₄

Purity: 96.0 to 111.0 %

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 179.97

Ref: 3B-M1907

4-Methoxycarbonylphenylboronic acid

CAS: 99768-12-4

Formula: C₈H₉BO₄

Purity: 97%

Color and Shape: Crystalline Powder

Molecular weight: 179.97

Ref: 10-F010805

4-(Methoxycarbonyl)phenylboronic Acid

Controlled Product

CAS: 99768-12-4

Applications 4-(Methoxycarbonyl)phenylboronic Acid is used in the synthesis and evaluation of several organic compounds including that of 4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate which is a potent inhibitor of intracellular NAAA activity. Also used in the design and synthesis of BMS-955176 which is a potent, orally active second generation HIV-1 maturation inhibitor.
References Nuzzi, A., et al.: Eur. J. Med. Chem., 111, 138 (2016); Rogueiro-Ren, A., et al.: ACS Med. Chem. Lett., 7, 568 (2016);

Formula: C₈H₉BO₄

Color and Shape: Neat

Molecular weight: 179.97

Ref: TR-M261675

4-Methoxycarbonylphenylboronic acid

CAS: 99768-12-4

4-Methoxycarbonylphenylboronic acid is an organic compound that can be synthesized from biphenyl. It is a diazonium salt with a bidentate ligand and a carbonyl group, which allows it to form an intermolecular hydrogen bond. The phenyl group of 4-methoxycarbonylphenylboronic acid can be oxidized to the corresponding carboxylic acid or reduced to the corresponding alcohol.
4-Methoxycarbonylphenylboronic acid is also soluble in halides, iodinations, and mercaptoacetic acid. This compound has been used as an acceptor in the oxidation of aluminium with diborane as a catalyst. 4-Methoxycarbonylphenylboronic acid has also been used to synthesize other compounds such as metronidazole (a drug) and erythromycin (an antibiotic).

Formula: C₈H₉BO₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 179.97 g/mol

Ref: 3D-FM32235