CAS 99891-31-3

fialuridine monophosphate

Description:

Fialuridine monophosphate, also known by its chemical name, is a nucleotide analog that has garnered interest primarily in the context of antiviral research, particularly for its potential use against hepatitis B virus. As a monophosphate derivative, it is characterized by the presence of a ribose sugar, a phosphate group, and a modified nucleobase that is structurally similar to uridine. This modification allows it to interfere with viral replication processes. Fialuridine monophosphate is typically soluble in water, which facilitates its bioavailability in biological systems. Its mechanism of action involves incorporation into viral RNA or DNA, leading to chain termination or misincorporation during nucleic acid synthesis. While it has shown promise in preclinical studies, the safety and efficacy of fialuridine monophosphate in clinical settings require thorough investigation. As with many nucleoside analogs, potential side effects and toxicity profiles are critical considerations in its development as a therapeutic agent. Overall, fialuridine monophosphate represents a significant area of interest in the ongoing search for effective antiviral treatments.

Formula: C₉H₁₁FIN₂O₈P

Synonyms:

• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-5-O-phosphono-β-D-arabinofuranosyl)-5-iodo-
• 1-(2-Deoxy-2-fluoro-5-O-phosphono-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyriMidinedione
• fialuridine monophosphate
• [(2R,3R,4S,5R)-4-fluoro-3-hydroxy-5-(5-iodo-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
• Fialuridine 5'-Monophosphate

Fialuridine 5’-monophosphate

CAS: 99891-31-3

Ref: 7W-GN4574

Fialuridine 5’-Monophosphate Disodium

Controlled Product

CAS: 99891-31-3

Formula: C₉H₉FIN₂O₈P·2Na

Color and Shape: Neat

Molecular weight: 452.069

Ref: TR-F335010

Fialuridine 5'-monophosphate

CAS: 99891-31-3

Fialuridine 5'-monophosphate is an analog of fialuridine, a drug used to treat HIV. Fialuridine 5'-monophosphate inhibits mitochondrial DNA synthesis by inhibiting hepg2 in the mitochondria and blocks the conversion of uracil to thymine in nuclear DNA. The inhibition of these two processes prevents viral replication and cell division. Fialuridine 5'-monophosphate also has antioxidant properties that protect cells from oxidative damage induced by reactive oxygen species. This drug may be beneficial for cancer treatment as well as hepatitis C or herpes simplex virus infection.

Formula: C₉H₁₁FIN₂O₈P

Purity: Min. 95%

Molecular weight: 452.07 g/mol

Ref: 3D-NF16547