CAS 999-97-3

Hexamethyldisilazane

Description:

Hexamethyldisilazane (HMDS) is a chemical compound with the formula (CH₃)₃Si-NH-Si(CH₃)₃. It is a colorless, volatile liquid with a characteristic amine-like odor. HMDS is primarily used as a silylating agent in organic synthesis and as a reagent in the preparation of various silicon-containing compounds. Its structure features two trimethylsilyl groups attached to a nitrogen atom, which contributes to its reactivity and utility in modifying surfaces, particularly in the field of chromatography and material science. HMDS is known for its ability to enhance the stability and volatility of certain compounds, making it valuable in analytical chemistry. It is also used in the semiconductor industry for surface treatment and passivation. While HMDS is generally considered to have low toxicity, it should be handled with care due to its flammability and potential irritant properties. Proper safety measures, including the use of personal protective equipment, are recommended when working with this substance.

Formula: C₆H₁₉NSi₂

InChI: InChI=1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3

InChI key: InChIKey=FFUAGWLWBBFQJT-UHFFFAOYSA-N

SMILES: N([Si](C)(C)C)[Si](C)(C)C

Synonyms:

• 1,1,1,3,3,3-Hexamethyldisilazan
• 1,1,1,3,3,3-Hexamethyldisilazane
• 1,1,1,3,3,3-Hexametildisilazano
• 1,1,1-Trimethyl-N-(trimethylsilyl)silanamine
• 12058-1A
• A 166
• A 166 (silazane)
• Bis(trimethylsilyl)amine
• Di(trimethylsilyl)amine
• Disilazane, 1,1,1,3,3,3-hexamethyl-
• Dn-L 69
• Dow Corning 4-2839
• Dynasylan HMDS
• H 0089
• HMDS (silazane)
• Hexamethyldisilazane
• Hexamethyldisilylamine
• Hexamethylsilazane
• Hmd 3
• Hmds
• Hmds 1
• Hmds 3
• Ls 7150
• Nsc 93895
• OAP
• SE 31 (silazane)
• Se 31
• Sih 6110.1
• Silazan HMN
• Sz 31
• Sz 6079
• Tsl 8802
• Tsr 8802
• Z 6079
• [Dimethyl-(trimethylsilylamino)silyl]methane
• Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-
• 1,1,1,3,3,3,-HEXAMETHYLDISILA-
• 1,1,1,3,3,3-hexamethyl-disilazan
• hexamethyldisilazane(hmds)
• 1,1,1,3,3,3-Hexamithyl disilazane
• ((CH3)3Si)2NH
• Trimethyl-N-(trimethylsilyl)silanamine
• SILAZANE HMN
• tsl8802
• hexamethyl disilizane
• LABOTEST-BB LT01408762
• 1,1,1-trimethyl-n-(trimethylsilyl)-silanamin

1,1,1,3,3,3-Hexamethyldisilazane

CAS: 999-97-3

Formula: C₆H₁₉NSi₂

Purity: >96.0%(GC)

Color and Shape: Colorless to Almost colorless clear liquid

Molecular weight: 161.40

Ref: 3B-H0089

Hexamethyldisilazane, Electronic grade, 99+%

CAS: 999-97-3

Hexamethyldisilazane is used as a solvent in organic synthesis and organometallic chemistry. It is often used as an adhesion promoter for photoresist in photolithography. Further, it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical

Formula: C₆H₁₉NSi₂

Purity: 99+%

Color and Shape: Clear colorless, Liquid

Molecular weight: 161.40

Ref: 02-L16519

Hexamethyldisilazane, 98+%

CAS: 999-97-3

Hexamethyldisilazane is used as a solvent in organic synthesis and organometallic chemistry. It is often used as an adhesion promoter for photoresist in photolithography. Further, it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical

Formula: C₆H₁₉NSi₂

Purity: 98+%

Color and Shape: Liquid, Clear colorless to pale yellow

Molecular weight: 161.40

Ref: 02-A15139

Hexamethyldisilazane, min. 97%

CAS: 999-97-3

Hexamethyldisilazane, min. 97%

Formula: (CH₃)₃SiNHSi(CH₃)₃

Purity: min. 97%

Color and Shape: colorless liq.

Molecular weight: 161.40

Ref: 08-93-1413

Hexamethyldisilazane

CAS: 999-97-3

Formula: C₆H₁₉NSi₂

Purity: (GC) ≥ 98.0%

Color and Shape: Clear, colourless liquid

Molecular weight: 161.40

Ref: 7W-GK7882

Hexamethyldisilazane

CAS: 999-97-3

Hexamethyldisilazane

Formula: C₆H₁₉NSi₂

Purity: 98%

Color and Shape: clear.colourless liquid

Molecular weight: 161.39275g/mol

Ref: 54-OR3890

Hexamethyldisilazane

CAS: 999-97-3

S09625 - Hexamethyldisilazane

Formula: C₆H₁₉NSi₂

Purity: 98%

Color and Shape: Liquid, Clear Liquid

Molecular weight: 161.395

Ref: 10-S09625

Hexamethyldisilazane

CAS: 999-97-3

Formula: C₆H₁₉NSi₂

Molecular weight: 161.40

Ref: 4Z-S-154001

Hexamethyldisilazane

Controlled Product

CAS: 999-97-3

Applications Hexamethyldisilazane is used in the preparation of 5-azacytidine, an antineoplastic drug. Also used in the preparation of β3-AR agonists used in anti-stress formulations.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Vujjini, S. et al.: Org. Proc. Res. Dev., 17, 303 (2013); Xu, F. et al.: Org. Lett., 15, 1342 (2013);

Formula: C₆H₁₉NSi₂

Color and Shape: Neat

Molecular weight: 161.39

Ref: TR-H296700

1,1,1,3,3,3-HEXAMETHYLDISILAZANE, 99%

CAS: 999-97-3

Alkyl Silane - Conventional Surface Bonding
Aliphatic, fluorinated aliphatic or substituted aromatic hydrocarbon substituents are the hydrophobic entities which enable silanes to induce surface hydrophobicity. The organic substitution of the silane must be non-polar. The hydrophobic effect of the organic substitution can be related to the free energy of transfer of hydrocarbon molecules from an aqueous phase to a homogeneous hydrocarbon phase. A successful hydrophobic coating must eliminate or mitigate hydrogen bonding and shield polar surfaces from interaction with water by creating a non-polar interphase. Although silane and silicone derived coatings are in general the most hydrophobic, they maintain a high degree of permeability to water vapor. This allows coatings to breathe and reduce deterioration at the coating interface associated with entrapped water. Since ions are not transported through non-polar silane and silicone coatings, they offer protection to composite structures ranging from pigmented coatings to rebar reinforced concrete. A selection guide for hydrophobic silanes can be found on pages 22-31 of the Hydrophobicity, Hydrophilicity and Silane Surface Modification brochure.
Silane Cross-Coupling Agent
The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.
Trimethylsilyl Blocking Agent
Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.
ALD Material
Atomic layer deposition (ALD) is a chemically self-limiting deposition technique that is based on the sequential use of a gaseous chemical process. A thin film (as fine as -0.1 Å per cycle) results from repeating the deposition sequence as many times as needed to reach a certain thickness. The major characteristic of the films is the resulting conformality and the controlled deposition manner. Precursor selection is key in ALD processes, namely finding molecules which will have enough reactivity to produce the desired films yet are stable enough to be handled and safely delivered to the reaction chamber.
1,1,1,3,3,3-Hexamethyldisilazane; HMDS; HMDZ; Bis(trimethylsilyl)amine
<5 ppm chlorideStandard grade available, SIH6110.0Viscosity: 0.90 cStΔHcomb: 25,332 kJ/molΔHvap: 34.7 kJ/molDipole moment: 0.37 debyeSurface tension: 18.2 mN/mSpecific wetting surface: 485 m2/gVapor pressure, 50 °: 50 mmpKa: 7.55Photoresist adhesion promoterDielectric constant: 1000 Hz: 2.27Ea, reaction w/SiO2 surface: 73.7 kJ/molVersatile silylation reagentCreates hydrophobic surfacesConverts acid chlorides and alcohols to amines in a three-component reactionReacts with formamide and ketones to form pyrimidinesLithium reagent reacts w/ aryl chlorides or bromides to provide primary anilinesUsed to convert ketones to α-aminophosphonates

Formula: C₆H₁₉NSi₂

Purity: 99%

Color and Shape: Colourless Liquid

Molecular weight: 161.39

Ref: 3H-SIH6110.1

1,1,1,3,3,3-HEXAMETHYLDISILAZANE, 98%

CAS: 999-97-3

Alkyl Silane - Conventional Surface Bonding
Aliphatic, fluorinated aliphatic or substituted aromatic hydrocarbon substituents are the hydrophobic entities which enable silanes to induce surface hydrophobicity. The organic substitution of the silane must be non-polar. The hydrophobic effect of the organic substitution can be related to the free energy of transfer of hydrocarbon molecules from an aqueous phase to a homogeneous hydrocarbon phase. A successful hydrophobic coating must eliminate or mitigate hydrogen bonding and shield polar surfaces from interaction with water by creating a non-polar interphase. Although silane and silicone derived coatings are in general the most hydrophobic, they maintain a high degree of permeability to water vapor. This allows coatings to breathe and reduce deterioration at the coating interface associated with entrapped water. Since ions are not transported through non-polar silane and silicone coatings, they offer protection to composite structures ranging from pigmented coatings to rebar reinforced concrete. A selection guide for hydrophobic silanes can be found on pages 22-31 of the Hydrophobicity, Hydrophilicity and Silane Surface Modification brochure.
ALD Material
Atomic layer deposition (ALD) is a chemically self-limiting deposition technique that is based on the sequential use of a gaseous chemical process. A thin film (as fine as -0.1 Å per cycle) results from repeating the deposition sequence as many times as needed to reach a certain thickness. The major characteristic of the films is the resulting conformality and the controlled deposition manner. Precursor selection is key in ALD processes, namely finding molecules which will have enough reactivity to produce the desired films yet are stable enough to be handled and safely delivered to the reaction chamber.
Trimethylsilyl Blocking Agent
Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.
Silane Cross-Coupling Agent
The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.
Hexamethyldisilazane; HMDS; HMDZ; Bis(trimethylsilyl)amine
Viscosity: 0.90 cStLow chloride grade available, SIH6110.1ΔHcomb: 25,332 kJ/molΔHvap: 34.7 kJ/molDipole moment: 0.37 debyeSurface tension: 18.2 mN/mSpecific wetting surface: 485 m2/gVapor pressure, 50 °C: 50 mmpKa: 7.55Dielectric constant: 1000 Hz: 2.27Ea, reaction w/SiO2 surface: 73.7 kJ/moleReleases ammonia upon reactionVersatile silylation reagentTreatment of fumed silica renders it hydrophobicBoth trimethylsilyl groups usedConverts acid chlorides and alcohols to amines in a three-component reactionReacts with formamide and ketones to form pyrimidinesSilylations catalyzed by SIT8510.0 and other reagentsNafion SAC-13 has been shown to be a recyclable catalyst for the trimethylsilylation of primary, secondary, and tertiary alcohols in excellent yields and short reaction timesUsed to convert ketones to α-aminophosphonatesLithium reagent reacts with aryl chlorides or bromides to provide anilinesSummary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochureExtensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011

Formula: C₆H₁₉NSi₂

Purity: 98%

Color and Shape: Colourless Liquid

Molecular weight: 161.39

Ref: 3H-SIH6110.0

1,1,1,3,3,3-Hexamethyldisilazane (HMDS) pure, 98%

CAS: 999-97-3

Formula: C₆H₁₉NSi₂

Purity: min. 98%

Color and Shape: Clear, Colourless, Liquid

Molecular weight: 161.40

Ref: SR-28437