TNF

Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic …

Cepharanthine, a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation …

Lenalidomide is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and …

UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.

Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, …

Eburicoic acid exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage …

25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus …

Procurcumenol is an inhibitor of Nitric Oxide. Procurcumenol and epicurcumenol have inhibitory effects on release …

Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of …

TNF-α-IN-1 is an inhibitor of TNF-α.

Neocurdione is an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincialis. Neocurdione shows a …

Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark …

Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.

Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α2 and …

Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, …

GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor ( IC50: 8.6 nM …

5,7-Dimethoxyflavanone has anti-inflammatory activity.

Hyuganin D can inhibit LPS-induced NO and/or TNF-alpha production in mouse peritoneal macrophages.

RIPK-IN-4 is an effective and selective inhibitor of RIPK2. It also has excellent oral bioavailability …

Nec-4 is a potent inhibitor of receptor interacting protein 1 (RIP1)(IC50 of 2.6 μM),and is …

Liguiritigenin-7-O-D-Apiosyl-4'-O-D-Glucoside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and …

Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to …

GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain …

Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can …

Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, …

Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.

Lucidenic acid D2 is a nartural product from G. lucidum AF.

Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of …

GSK2593074A is a necroptosis inhibitor for dual-targeting to both RIP1 and RIP3.

7-O-Methylmorroniside exhibits anti-inflammatory activity.

Galeopsin shows potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α, it has anti-proliferative effect on …

25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus …

Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in …

Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara …

Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates …

Prim-O-glucosylcimifugin can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion …

α-Humulene is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory …

WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents …

HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 …

GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).

8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced …

5-Hydroxy-3',4',7-trimethoxyflavone has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC …

R-7050 is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.

Physcion 8-O-β-D-glucopyranoside has anti-inflammatory and anti-cancer activities. Physcion 8-O-β-D-glucopyranoside can be used in studies about …

3,3',4',5,6,7,8-Heptamethoxyflavone(HMF) has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibits collagenase activity …

GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to …

Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and …

Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially …

Hederacoside D is a bioactive saponins from Hedera helix.

RIPA-56 is an inhibitor of RIP1

N-Formyl-Met-Leu-Phe (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors …

Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is …

MALTOTETRAOSE are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial …

GSK872 HCl is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain …

Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; …

Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with …

Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of …

GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 …

LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.

Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress …

UTL-5g is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including …

GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance …

Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα2(25-35)-induced neurotoxicity in PC12 cells, …

Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation …

1. Linalool, a natural compound of the essential oils, has been shown to have antinociceptive, …

Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway …

1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced …

(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.