TNF
TNF (Tumor Necrosis Factor) inhibitors are compounds that block the activity of TNF, a cytokine involved in inflammation and the regulation of apoptosis. TNF can induce apoptosis in some cell types while promoting survival and inflammation in others. Inhibiting TNF is crucial in the treatment of autoimmune diseases, chronic inflammatory conditions, and certain cancers. TNF inhibitors help to modulate the immune response and reduce tissue damage caused by excessive inflammation. At CymitQuimica, we provide a diverse range of high-quality TNF inhibitors to support your research in immunology, inflammation, and apoptosis.
Found 65 products of "TNF"
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Boserolimab
CAS:Boserolimab (MK-5890) is a chimeric, humanized IgG1κ antibody that targets the signaling regulatory protein CD27 in mice.Purity:95% - 95%Color and Shape:LiquidTecaginlimab
CAS:Tecaginlimab (BNT-312), an Fc-inert bispecific antibody, targets CD40/4-1BB to boost tumor immunity.Color and Shape:LiquidDalnicastobart
CAS:Dalnicastobart (LVGN-7409) is a humanized monoclonal antibody targeting CD40/TNFRSF5 with agonist activity, immunostimulatory and antitumor.Purity:95% - 97.4% (SDS-PAGE); 97.8% (SEC-HPLC)Color and Shape:LiquidMolecular weight:146.33 kDaAfelimomab
CAS:Afelimomab (MAK 195F), a F(ab')2 fragment of an anti-tumor necrosis factor monoclonal antibody, is utilized in sepsis research [1].Color and Shape:LiquidTNF-α-IN-1
CAS:TNF-α-IN-1 is a TNF-α inhibitor.Formula:C16H14ClN3O5Purity:98.82%Color and Shape:SolidMolecular weight:363.75Ref: TM-T13175
1mg56.00€5mg120.00€10mg178.00€25mg330.00€50mg505.00€100mg713.00€1mL*10mM (DMSO)203.00€SPD304 dihydrochloride
CAS:SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.
Formula:C32H34Cl2F3N3O2Purity:99.25%Color and Shape:SolidMolecular weight:620.53UCB-5307
CAS:UCB-5307 inhibits TNFR1, binds TNFα with 9 nM KD, shows slow kinetics (KD=6 nM), and penetrates hTNF/hTNFR1 complexes.Formula:C22H21N3OPurity:98.76%Color and Shape:SolidMolecular weight:343.42PK68
CAS:PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Formula:C22H24N4O3SPurity:98.09% - 99.64%Color and Shape:SolidMolecular weight:424.52Ref: TM-T12493
1mg81.00€5mg170.00€10mg274.00€25mg518.00€50mg747.00€100mg938.00€1mL*10mM (DMSO)188.00€BMS-561392
CAS:BMS-561392 (DPC333) is a tumor necrosis factor-α ( TNF-α) Invertase inhibitor.Formula:C27H32N4O4Purity:99.16%Color and Shape:SolidMolecular weight:476.57Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurity:99.18%Color and Shape:SolidMolecular weight:512.46C 87
CAS:C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.Formula:C24H15ClN6O3SPurity:≥98%Color and Shape:SolidMolecular weight:502.93CDC801
CAS:CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.
Formula:C23H24N2O5Purity:99.61%Color and Shape:SolidMolecular weight:408.45TNF-α-IN-2
CAS:TNF-α-IN-2 is orally active TNFα inhibitor that distorts the TNFα trimer, causing abnormal signal transduction when it binds to TNFR1, rheumatoid arthritis.Formula:C25H21ClF2N6OPurity:99.92%Color and Shape:SolidMolecular weight:494.92TNF-α-IN-14
CAS:TNF-α-IN-14, a potent TNFα inhibitor, exhibits a selective inhibition profile with an IC50 of 1.1 µM and demonstrates antiinflammatory properties (WO2001072735A2; compound 12) [1].Formula:C22H26O6Color and Shape:SolidMolecular weight:386.44TNF-α-IN-12
CAS:TNF-α-IN-12, a TNF-α inhibitor with an IC50 of 0.1 μM, can reduce TNF-α blood levels [1].Formula:C21H22O6Color and Shape:SolidMolecular weight:370.4
