TNF
TNF (Tumor Necrosis Factor) inhibitors are compounds that block the activity of TNF, a cytokine involved in inflammation and the regulation of apoptosis. TNF can induce apoptosis in some cell types while promoting survival and inflammation in others. Inhibiting TNF is crucial in the treatment of autoimmune diseases, chronic inflammatory conditions, and certain cancers. TNF inhibitors help to modulate the immune response and reduce tissue damage caused by excessive inflammation. At CymitQuimica, we provide a diverse range of high-quality TNF inhibitors to support your research in immunology, inflammation, and apoptosis.
Found 92 products of "TNF"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Nodinitib-1
CAS:<p>Nodinitib-1 (CID-1088438) is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.</p>Formula:C14H13N3O2SPurity:99.97% - >99.99%Color and Shape:SolidMolecular weight:287.34C25-140
CAS:<p>C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.</p>Formula:C26H31N7OPurity:98.81%Color and Shape:SolidMolecular weight:457.57(Rac)-Benpyrine
CAS:<p>(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.</p>Formula:C16H16N6OPurity:98.44%Color and Shape:SolidMolecular weight:308.34Roquinimex
CAS:<p>Roquinimex (FCF89) (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and</p>Formula:C18H16N2O3Purity:97.69%Color and Shape:SolidMolecular weight:308.33LASSBio-1135
CAS:<p>LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.</p>Formula:C18H14N4Purity:99.09%Color and Shape:SolidMolecular weight:286.33UTL-5g
CAS:<p>UTL-5g is a chemoprotective TNF-α inhibitor reducing cisplatin side effects and toxicity in liver, kidneys, and blood.</p>Formula:C11H8Cl2N2O2Purity:99.83%Color and Shape:SolidMolecular weight:271.1STING-IN-2
CAS:<p>STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. STING-IN-2 can be used for autoinflammatory disease research.</p>Formula:C15H16N2O4Purity:98.61%Color and Shape:SolidMolecular weight:288.3Tulisokibart
CAS:<p>Tulisokibart (PRA023) is a humanized anti-TNFSF15 monoclonal antibody used to study colon cancer.</p>Purity:98.38% (SEC-HPLC) - > 95%Color and Shape:LiquidLicaminlimab
<p>Licaminlimab (OCS-02) is a single-chain antibody fragment targeting TNF alpha, an inflammatory cytokine.</p>Color and Shape:Odour LiquidToralizumab
CAS:<p>Toralizumab: humanized mAb targeting CD40L to curb T cell signaling and explore SLE treatment.</p>Color and Shape:LiquidMolecular weight:148.43 (kD)Azintuxizumab
CAS:<p>Azintuxizumab, an IgG4 bispecific antibody, targets BCMA, offering dual-action immunotherapy for relapsed/refractory multiple myeloma in preclinical studies.</p>Purity:95% - 95%Color and Shape:LiquidInezetamab
CAS:<p>Inezetamab is a bispecific anti- CD40 and anti- MSLN IgG1 monoclonal antibody [1] .</p>Purity:95% - 95%Color and Shape:LiquidBleselumab
CAS:<p>Bleselumab (ASKP 1240) is a humanised monoclonal antibody targeting CD40, inhibiting immune responses, organ transplant rejection.</p>Purity:95%Color and Shape:LiquidTabalumab
CAS:<p>Tabalumab (LY2127399) is a humanised monoclonal antibody targeting BAFF that neutralises both soluble and membrane-bound forms of BLyS , autoimmune diseases.</p>Purity:95%Color and Shape:LiquidIvuxolimab
CAS:<p>Ivuxolimab is a human IgG2 antibody that acts as an OX40 agonist, promoting T cell responses for anti-tumor immunity research.</p>Purity:95% - 95%Color and Shape:LiquidCifurtilimab
CAS:<p>Cifurtilimab (SEA-CD40) is a humanised monoclonal antibody acting as a CD40 agonist. It enhances binding to activated FcγRIIIa, anticancer.</p>Purity:95%Color and Shape:LiquidAfimkibart
CAS:<p>Afimkibart (PF06480605) is a humanised monoclonal antibody targeting TL1A (TNF-like Ligand 1A), which blocks TL1A-DR3 (death domain receptor 3) signalling on restrictive immune cells and fibroblasts. It can be used for inflammatory bowel disease and ulcerative colitis.</p>Purity:95% - 95%Color and Shape:SoildRavagalimab
CAS:<p>Ravagalimab (ABBV-323) is a CD40 antagonist monoclonal antibody, investigated for Crohn’s disease and Sjögren’s syndrome to evaluate immune modulation.</p>Purity:95% - 95%Color and Shape:LiquidFrexalimab
CAS:<p>Frexalimab (SAR441344; INX-021), a monoclonal antibody that targets the CD40 ligand (CD40L), shows promise for research in multiple sclerosis [1].</p>Color and Shape:LiquidAfelimomab
CAS:<p>Afelimomab (MAK 195F), a F(ab')2 fragment of an anti-tumor necrosis factor monoclonal antibody, is utilized in sepsis research [1].</p>Color and Shape:LiquidTecaginlimab
CAS:<p>Tecaginlimab (BNT-312), an Fc-inert bispecific antibody, targets CD40/4-1BB to boost tumor immunity.</p>Color and Shape:LiquidAnti-Mouse TNFR2 Antibody (TR75-54.7)
<p>Anti-Mouse TNFR2 Antibody is an Armenian Hamster-derived IgG inhibitor specifically targeting mouse TNFR2.</p>Color and Shape:Odour LiquidIratumumab
CAS:<p>Iratumumab (MDX-060), a human IgG1κ anti-CD30 monoclonal antibody, halts CD30+ tumor growth, used in HL and ALCL research.</p>Color and Shape:LiquidIA-14069
CAS:<p>IA-14069 is a TNF-a inhibitor with anti-inflammatory activity and pro-inflammatory cytokine production, and is used in the study of colon cancer.</p>Formula:C20H15ClF2O4Color and Shape:SoildMolecular weight:392.78Cot inhibitor-2
CAS:<p>Cot inhibitor-2: Potent, selective Tpl2/MAP3K8 blocker. IC50: 1.6 nM; hampers LPS-induced TNF-α, IC50: 0.3 μM. Orally active.</p>Formula:C26H25Cl2FN8Purity:98.87%Color and Shape:SolidMolecular weight:539.43Selicrelumab
CAS:<p>Selicrelumab (RG-7876) is an antibody targeting CD40 with potential anti-tumor activity for the study of pancreatic cancer.</p>Purity:98.7% (SDS-PAGE); 95.2% (SEC-HPLC) - 98.7% (SDS-PAGE); 95.2% (SEC-HPLC)Color and Shape:LiquidVU0285655-1
CAS:<p>VU0285655-1, a PLD2 inhibitor, halts PLD2-deficient cell growth and protects against high glucose-induced cell death. Used in diabetic retinopathy research.</p>Formula:C25H27N5O2Purity:99.73%Color and Shape:SolidMolecular weight:429.51TNF-α-IN-1
CAS:<p>TNF-α-IN-1 is a TNF-α inhibitor.</p>Formula:C16H14ClN3O5Purity:98.82%Color and Shape:SolidMolecular weight:363.75UCB-5307
CAS:<p>UCB-5307 inhibits TNFR1, binds TNFα with 9 nM KD, shows slow kinetics (KD=6 nM), and penetrates hTNF/hTNFR1 complexes.</p>Formula:C22H21N3OPurity:98.76%Color and Shape:SolidMolecular weight:343.42Cot inhibitor-1
CAS:<p>Cot inhibitor-1 selectively blocks Tpl2 kinase, reducing TNF-alpha in blood (IC50: 5.7 nM). It may treat arthritis, IBD, and certain cancers.</p>Formula:C27H27Cl2FN8Purity:98.59%Color and Shape:SolidMolecular weight:553.46Mitazalimab
CAS:<p>Mitazalimab (ADC-1013/JNJ-64457107) is a CD40 agonist that stimulates T cells to attack tumors and remodels the tumor microenvironment.</p>Purity:95.1% (SDS-PAGE); 98.7% (SEC-HPLC) - 95.1% (SDS-PAGE); 98.7% (SEC-HPLC)Color and Shape:LiquidSPD304 dihydrochloride
CAS:<p>SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.</p>Formula:C32H34Cl2F3N3O2Purity:99.25%Color and Shape:SolidMolecular weight:620.53GSK2593074A
CAS:<p>GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.</p>Formula:C27H23N5OSPurity:99.76%Color and Shape:SolidMolecular weight:465.57BMS-561392
CAS:<p>BMS-561392 (DPC333) is a tumor necrosis factor-α ( TNF-α) Invertase inhibitor.</p>Formula:C27H32N4O4Purity:99.16%Color and Shape:SolidMolecular weight:476.57PK68
CAS:<p>PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.</p>Formula:C22H24N4O3SPurity:98.09% - 99.64%Color and Shape:SolidMolecular weight:424.52Trovafloxacin mesylate
CAS:<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Formula:C21H19F3N4O6SPurity:99.18%Color and Shape:SolidMolecular weight:512.46C 87
CAS:<p>C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.</p>Formula:C24H15ClN6O3SPurity:≥98%Color and Shape:SolidMolecular weight:502.93Boserolimab
CAS:<p>Boserolimab (MK-5890) is a chimeric, humanized IgG1κ antibody that targets the signaling regulatory protein CD27 in mice.</p>Color and Shape:LiquidCDC801
CAS:<p>CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.</p>Formula:C23H24N2O5Purity:99.61%Color and Shape:SolidMolecular weight:408.45TNF-α-IN-2
CAS:<p>TNF-α-IN-2 is orally active TNFα inhibitor that distorts the TNFα trimer, causing abnormal signal transduction when it binds to TNFR1, rheumatoid arthritis.</p>Formula:C25H21ClF2N6OPurity:99.92%Color and Shape:SolidMolecular weight:494.92TNF-α-IN-14
CAS:<p>TNF-α-IN-14, a potent TNFα inhibitor, exhibits a selective inhibition profile with an IC50 of 1.1 µM and demonstrates antiinflammatory properties (WO2001072735A2; compound 12) [1].</p>Formula:C22H26O6Color and Shape:SolidMolecular weight:386.44TNF-α-IN-12
CAS:<p>TNF-α-IN-12, a TNF-α inhibitor with an IC50 of 0.1 μM, can reduce TNF-α blood levels [1].</p>Formula:C21H22O6Color and Shape:SolidMolecular weight:370.4
